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A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population.

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  • المؤلفون: Cha PC;Cha PC; Zembutsu H; Takahashi A; Kubo M; Kamatani N; Nakamura Y
  • المصدر:
    Journal of human genetics [J Hum Genet] 2012 Apr; Vol. 57 (4), pp. 235-7. Date of Electronic Publication: 2012 Feb 09.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Pub. Group Country of Publication: England NLM ID: 9808008 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-232X (Electronic) Linking ISSN: 14345161 NLM ISO Abbreviation: J Hum Genet Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2009- : London : Nature Pub. Group
      Original Publication: Tokyo : Springer-Verlag, c1998-
    • الموضوع:
      Genome-Wide Association Study* ; Polymorphism, Single Nucleotide*; Asian People/*genetics ; Gallbladder Neoplasms/*genetics ; Receptors, Cell Surface/*genetics ; Tumor Suppressor Proteins/*genetics; Aged ; Case-Control Studies ; DCC Receptor ; Female ; Gallbladder Neoplasms/diagnosis ; Gene Frequency ; Genetic Predisposition to Disease ; Genetics, Population ; Genome, Human ; Humans ; Logistic Models ; Loss of Heterozygosity ; Male ; Middle Aged
    • نبذة مختصرة :
      Gallbladder cancer (GC) is a relatively uncommon cancer with higher incidence in certain areas including Japan. Because of the difficulty in diagnosis, prognosis of GC is very poor. To identify genetic determinants of GC, we conducted a genome-wide association study (GWAS) in 41 GC patients and 866 controls. Association between each single-nucleotide polymorphism (SNP) with GC susceptibility was evaluated by multivariate logistic regression analysis conditioned on age and gender of subjects. SNPs that showed suggestive association (P<1 × 10(-4)) with GC were further examined in 30 cases and 898 controls. SNP rs7504990 in the DCC (deleted in colorectal cancer, 18q21.3) that encodes a netrin 1 receptor achieved a combined P-value of 7.46 × 10(-8) (OR=6.95; 95% CI=3.43-14.08). Subsequent imputation analysis identified multiple SNPs with similarly strong associations in an adjacent genomic region, where loss of heterozygosity was reported in GC and other cancers. Reduced expression of DCC was indicated to be associated with the poorly differentiated histological type, increased proliferation and metastasis through loss of adhesiveness. However, due to the limited sample size investigated here, further replication study and functional analysis would be necessary to further confirm the result of the association.
    • الرقم المعرف:
      0 (DCC Receptor)
      0 (DCC protein, human)
      0 (Receptors, Cell Surface)
      0 (Tumor Suppressor Proteins)
    • الموضوع:
      Date Created: 20120210 Date Completed: 20120813 Latest Revision: 20221207
    • الموضوع:
      20221213
    • الرقم المعرف:
      10.1038/jhg.2012.9
    • الرقم المعرف:
      22318345