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Serum perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations and liver function biomarkers in a population with elevated PFOA exposure.

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  • معلومة اضافية
    • المصدر:
      Publisher: National Institute of Environmental Health Sciences Country of Publication: United States NLM ID: 0330411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-9924 (Electronic) Linking ISSN: 00916765 NLM ISO Abbreviation: Environ Health Perspect Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences.
    • الموضوع:
      Environmental Exposure* ; Liver Function Tests*; Alkanesulfonic Acids/*blood ; Biomarkers/*blood ; Caprylates/*blood ; Environmental Pollutants/*blood ; Fluorocarbons/*blood; Adult ; Alanine Transaminase/blood ; Alkanesulfonic Acids/toxicity ; Caprylates/toxicity ; Environmental Pollutants/toxicity ; Female ; Fluorocarbons/toxicity ; Humans ; Male ; Middle Aged ; gamma-Glutamyltransferase/blood
    • نبذة مختصرة :
      Background: Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) persist in the environment and are found in relatively high concentrations in animal livers. Studies in humans have reported inconsistent associations between PFOA and liver enzymes.
      Objectives: We examined the cross-sectional association between serum PFOA and PFOS concentrations with markers of liver function in adults.
      Methods: The C8 Health Project collected data on 69,030 persons; of these, a total of 47,092 adults were included in the present analysis. Linear regression models were fitted for natural log (ln)-transformed values of alanine transaminase (ALT), γ-glutamyltransferase (GGT), and direct bilirubin on PFOA, PFOS, and potential confounders. Logistic regression models were fitted comparing deciles of PFOA or PFOS in relation to high biomarker levels. A multilevel analysis comparing the evidence for association of PFOA with liver function at the individual level within water districts to that at the population level between water districts was also performed.
      Results: ln-PFOA and ln-PFOS were associated with ln-ALT in linear regression models [PFOA: coefficient, 0.022; 95% confidence interval (CI): 0.018, 0.025; PFOS: coefficient, 0.020; 95% CI: 0.014, 0.026] and with raised ALT in logistic regression models [with a steady increase in the odds ratio (OR) estimates across deciles of PFOA and PFOS; PFOA: OR = 1.10; 95% CI: 1.07, 1.13; PFOS: OR = 1.13; 95% CI: 1.07, 1.18]. There was less consistent evidence of an association of PFOA and GGT or bilirubin. The relationship with bilirubin appears to rise at low levels of PFOA and to fall again at higher levels.
      Conclusions: These results show a positive association between PFOA and PFOS concentrations and serum ALT level, a marker of hepatocellular damage.
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    • الرقم المعرف:
      0 (Alkanesulfonic Acids)
      0 (Biomarkers)
      0 (Caprylates)
      0 (Environmental Pollutants)
      0 (Fluorocarbons)
      947VD76D3L (perfluorooctanoic acid)
      9H2MAI21CL (perfluorooctane sulfonic acid)
      EC 2.3.2.2 (gamma-Glutamyltransferase)
      EC 2.6.1.2 (Alanine Transaminase)
    • الموضوع:
      Date Created: 20120201 Date Completed: 20120822 Latest Revision: 20211021
    • الموضوع:
      20240628
    • الرقم المعرف:
      PMC3346788
    • الرقم المعرف:
      10.1289/ehp.1104436
    • الرقم المعرف:
      22289616