Dermal mast cells affect the development of sunlight-induced skin tumours.

Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9301549 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0625 (Electronic) Linking ISSN: 09066705 NLM ISO Abbreviation: Exp Dermatol Subsets: MEDLINE

Original Publication: Copenhagen : Munksgaard, c1992-

Mast Cells/*radiation effects ; Neoplasms, Radiation-Induced/*etiology ; Skin Neoplasms/*etiology ; Sunlight/*adverse effects; Animals ; Histamine/physiology ; Humans ; Immune Tolerance/radiation effects ; Interleukin-10/physiology ; Interleukin-4/physiology ; Mast Cells/immunology ; Mast Cells/pathology ; Mast Cells/physiology ; Models, Biological ; Neoplasms, Radiation-Induced/immunology ; Neoplasms, Radiation-Induced/pathology ; Neoplasms, Radiation-Induced/physiopathology ; Nerve Growth Factor/physiology ; Neuropeptides/physiology ; Skin Neoplasms/immunology ; Skin Neoplasms/pathology ; Skin Neoplasms/physiopathology ; Transforming Growth Factor beta/physiology ; Tumor Microenvironment/physiology ; Tumor Necrosis Factor-alpha/physiology ; Ultraviolet Rays/adverse effects ; Vascular Endothelial Growth Factor A/physiology

Ultraviolet (UV) radiation contained in sunlight is considered a major risk in the induction of skin cancer. While mast cells are best known for their role in allergic responses, they have also been shown to play a crucial role in suppressing the anti-tumour immune response following UV exposure. Evidence is now emerging that UV may also trigger mast cell release of cutaneous tissue remodelling and pro-angiogenic factors. In this review, we will focus on the cellular and molecular mechanisms by which UV recruits and then activates mast cells to initiate and promote skin cancer development.
(© 2012 John Wiley & Sons A/S.)

0 (IL10 protein, human)
0 (IL4 protein, human)
0 (Neuropeptides)
0 (Transforming Growth Factor beta)
0 (Tumor Necrosis Factor-alpha)
0 (VEGFA protein, human)
0 (Vascular Endothelial Growth Factor A)
130068-27-8 (Interleukin-10)
207137-56-2 (Interleukin-4)
820484N8I3 (Histamine)
9061-61-4 (Nerve Growth Factor)

Date Created: 20120127 Date Completed: 20120716 Latest Revision: 20131121

20250114

10.1111/j.1600-0625.2012.01438.x

22276860