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ABCG2 null alleles define the Jr(a-) blood group phenotype.

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  • المؤلفون: Zelinski T;Zelinski T; Coghlan G; Liu XQ; Reid ME
  • المصدر:
    Nature genetics [Nat Genet] 2012 Jan 15; Vol. 44 (2), pp. 131-2. Date of Electronic Publication: 2012 Jan 15.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: New York, NY : Nature Pub. Co., c1992-
    • الموضوع:
      ATP-Binding Cassette Transporters/*genetics ; Blood Group Antigens/*genetics ; Chromosomes, Human, Pair 4/*genetics ; Neoplasm Proteins/*genetics; ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Base Sequence ; Female ; Homozygote ; Humans ; Male ; Molecular Sequence Data ; Polymorphism, Single Nucleotide ; Sequence Analysis, DNA
    • نبذة مختصرة :
      The high-incidence erythrocyte blood group antigen Jr(a) has been known in transfusion medicine for over 40 years. To identify the gene encoding Jr(a), we performed SNP analysis of genomic DNA from six Jr(a-) individuals. All individuals shared a homozygous region of 397,000 bp at chromosome 4q22.1 that contained the gene ABCG2, and DNA sequence analysis showed that ABCG2 null alleles define the Jr(a-) phenotype.
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    • الرقم المعرف:
      0 (ABCG2 protein, human)
      0 (ATP Binding Cassette Transporter, Subfamily G, Member 2)
      0 (ATP-Binding Cassette Transporters)
      0 (Blood Group Antigens)
      0 (Neoplasm Proteins)
    • الموضوع:
      Date Created: 20120117 Date Completed: 20120330 Latest Revision: 20211021
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.1038/ng.1075
    • الرقم المعرف:
      22246507