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Antimycobacterial activity of salicylanilide benzenesulfonates.

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  • المؤلفون: Krátký M;Krátký M; Vinšová J; Rodriguez NG; Stolaříková J
  • المصدر:
    Molecules (Basel, Switzerland) [Molecules] 2012 Jan 05; Vol. 17 (1), pp. 492-503. Date of Electronic Publication: 2012 Jan 05.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Basel, Switzerland : MDPI, c1995-
    • الموضوع:
      Anti-Bacterial Agents/*pharmacology ; Benzenesulfonates/*pharmacology ; Esters/*pharmacology ; Mycobacterium/*drug effects ; Salicylanilides/*pharmacology; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Benzenesulfonates/chemical synthesis ; Benzenesulfonates/chemistry ; Drug Design ; Esterification ; Esters/chemical synthesis ; Esters/chemistry ; Hydrophobic and Hydrophilic Interactions ; Microbial Sensitivity Tests ; Salicylanilides/chemical synthesis ; Salicylanilides/chemistry
    • نبذة مختصرة :
      A series of eighteen novel esters of salicylanilides with benzenesulfonic acid were designed, synthesized and characterized by IR, ¹H-NMR and ¹³C-NMR. They were evaluated in vitro as potential antimycobacterial agents towards Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. In general, the minimum inhibitory concentrations range from 1 to 500 µmol/L. The most active compound against M. tuberculosis was 4-chloro-2-(4-(trifluoromethyl)phenylcarbamoyl)-phenyl benzenesulfonate, with MIC of 1 µmol/L and towards M. kansasii its isomer 5-chloro-2-(4-(trifluoromethyl)phenylcarbamoyl)phenyl benzenesulfonate (MIC of 2-4 µmol/L). M. avium was the less susceptible strain. However, generally, salicylanilide benzenesulfonates did not surpass the activity of other salicylanilide esters with carboxylic acids.
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    • الرقم المعرف:
      0 (Anti-Bacterial Agents)
      0 (Benzenesulfonates)
      0 (Esters)
      0 (Salicylanilides)
    • الموضوع:
      Date Created: 20120107 Date Completed: 20120501 Latest Revision: 20211021
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC6268226
    • الرقم المعرف:
      10.3390/molecules17010492
    • الرقم المعرف:
      22222908