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Design and control of a ferromagnetic coded micro-carrier biochip sensor for multiplex detection of antibodies.

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  • المؤلفون: Chang RS;Chang RS; Tsai JZ; Li TY
  • المصدر:
    Sensors (Basel, Switzerland) [Sensors (Basel)] 2011; Vol. 11 (8), pp. 7851-64. Date of Electronic Publication: 2011 Aug 11.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101204366 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1424-8220 (Electronic) Linking ISSN: 14248220 NLM ISO Abbreviation: Sensors (Basel) Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Basel, Switzerland : MDPI, c2000-
    • الموضوع:
      Biosensing Techniques*; Antibodies/*chemistry ; Antigens/*chemistry ; Biotechnology/*methods ; Enzyme-Linked Immunosorbent Assay/*methods ; Magnets/*chemistry ; Microarray Analysis/*methods; Animals ; Biocompatible Materials ; Crystallization ; Drosophila melanogaster ; Electronic Data Processing ; Equipment Design ; Humans ; Magnetics ; Nanotechnology/methods
    • نبذة مختصرة :
      This paper describes a method for producing a novel type of ferromagnetic coded micro-carrier. The ferromagnetic coded micro-carriers are about 200 μm in length, 200 μm in width and 50 μm in thickness, and contain eight code elements with two distinguishable codes (hollow and solid), allowing for 2(8) unique codes. The code shapes include rectangle, circle, etc. Differently shaped coded micro-carriers could carry different antigens for detection of its complementary antibody. These many shapes of coded micro-carriers would be used simultaneously allowing us to make multiple detections for different antibodies at the same time. A molding process is applied for fabrication of the ferromagnetically coded micro-carriers where Fe material (Fe powder mixed with binder) is shaped in many tiny molds to produce the coded shapes used for identification of the bio-molecules. Magnetic force is used to control the movement and location of the ferromagnetic coded micro-carriers to prevent the loss during the hybridization process. The results of image process and analysis system testing are satisfactory. The results of our micro-carrier detection system for two sets of R and B color analysis are proportional to those obtained from ELISA antibody detection.
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    • Contributed Indexing:
      Keywords: ferromagnetic coded micro-carrier; hybridization; magnetic force
    • الرقم المعرف:
      0 (Antibodies)
      0 (Antigens)
      0 (Biocompatible Materials)
    • الموضوع:
      Date Created: 20111214 Date Completed: 20120628 Latest Revision: 20211021
    • الموضوع:
      20221213
    • الرقم المعرف:
      PMC3231740
    • الرقم المعرف:
      10.3390/s110807851
    • الرقم المعرف:
      22164049