Genetic response to an environmental pathogenic agent: HLA-DQ and onchocerciasis in northwestern Ecuador.

Publisher: Wiley Blackwell Country of Publication: England NLM ID: 0331072 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-0039 (Electronic) Linking ISSN: 00012815 NLM ISO Abbreviation: Tissue Antigens Subsets: MEDLINE

Publication: <2015>: [Oxford] : Wiley Blackwell
Original Publication: 1971- : Copenhagen, Munksgaard.

HLA-DQ alpha-Chains/*genetics ; HLA-DQ beta-Chains/*genetics ; Onchocerca/*immunology ; Onchocerciasis/*genetics; Adolescent ; Adult ; Aged ; Alleles ; American Indian or Alaska Native ; Animals ; Black People ; Case-Control Studies ; Child ; DNA Primers ; Disease Susceptibility ; Ecuador/epidemiology ; Female ; Gene Frequency ; Gene-Environment Interaction ; HLA-DQ alpha-Chains/immunology ; HLA-DQ beta-Chains/immunology ; Haplotypes ; Histocompatibility Testing ; Humans ; Male ; Middle Aged ; Nucleic Acid Amplification Techniques ; Onchocerciasis/ethnology ; Onchocerciasis/immunology ; Polymorphism, Genetic

The aim of this study is to explore human leukocyte antigen (HLA)-DQ variability in two populations (Cayapas Amerindians and Afro-Ecuadorians) who live near one another along the Cayapa River and who are exposed to the same environmental stresses, such as infection by Onchocerca volvulus. HLA-DQA1 and HLA-DQB1 of 149 unrelated individuals (74 Cayapas and 75 Afro-Ecuadorians) have been analyzed. HLA high-resolution molecular typing was performed by sequence-based typing, sequence-specific oligonucleotides hybridization and sequence-specific primer (SSP) amplification. The comparison between affected (cases) and unaffected people (controls) in both populations shows the key role of several HLA-DQA1 alleles in susceptibility and protection against onchocerciasis. In both populations, there is strong evidence related to the protective role of DQA1*0401 against onchocerciasis. Alleles HLA-DQA1*0102 and *0103 seem to represent risk factors in Afro-Ecuadorians, while HLA-DQA1*0301 is only a suggestive susceptibility allele in Cayapas. These findings represent new positive/negative associations with onchocerciasis in South America, whereas previous findings pertained only to African populations.
(© 2011 John Wiley & Sons A/S.)

0 (DNA Primers)
0 (HLA-DQ alpha-Chains)
0 (HLA-DQ beta-Chains)
0 (HLA-DQA1 antigen)
0 (HLA-DQB1 antigen)

Date Created: 20111129 Date Completed: 20120814 Latest Revision: 20221207

20250114

10.1111/j.1399-0039.2011.01811.x

22117902