Polymorphisms in Ly6 genes in Msq1 encoding susceptibility to mouse adenovirus type 1.

Publisher: Springer-Verlag Country of Publication: United States NLM ID: 9100916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1777 (Electronic) Linking ISSN: 09388990 NLM ISO Abbreviation: Mamm Genome Subsets: MEDLINE

Publication: New York, NY : Springer-Verlag
Original Publication: New York, NY, USA : Springer International, c1991-

Genetic Predisposition to Disease* ; Polymorphism, Genetic*; Adenoviridae/*physiology ; Adenoviridae Infections/*veterinary ; Antigens, Ly/*genetics ; Chromosomes, Mammalian/*genetics ; Mice/*genetics ; Rodent Diseases/*genetics; Adenoviridae Infections/genetics ; Adenoviridae Infections/virology ; Amino Acid Sequence ; Animals ; Antigens, Ly/chemistry ; Female ; Male ; Mice/virology ; Mice, Inbred Strains ; Molecular Sequence Data ; Rodent Diseases/virology ; Sequence Alignment

Strain-specific differences in susceptibility to mouse adenovirus type 1 (MAV-1) are linked to the quantitative trait locus Msq1 on mouse chromosome 15. This region contains 14 Ly6 or Ly6-related genes, many of which are known to be expressed on the surface of immune cells, suggesting a possible role in host defense. We analyzed these genes for polymorphisms between MAV-1-susceptible and MAV-1-resistant inbred mouse strains. Sequencing of cDNAs identified 12 coding-region polymorphisms in 2010109I03Rik, Ly6e, Ly6a, Ly6c1, and Ly6c2, six of which were nonsynonymous and five of which were previously unlisted in dbSNP Build 132. We also clarified sequence discrepancies in GenBank for the coding regions of I830127L07Rik and Ly6g. Additionally, Southern blotting revealed size polymorphisms within the DNA regions of Ly6e, Ly6a, and Ly6g. Collectively, these genetic variations have implications for the structure, function, and/or expression of Ly6 and Ly6-related genes that may contribute to the observed strain-specific differences in susceptibility to MAV-1.

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R01 AI068645 United States AI NIAID NIH HHS; R01 AI068645-05 United States AI NIAID NIH HHS

0 (Antigens, Ly)
0 (Ly6 protein, mouse)

Date Created: 20111122 Date Completed: 20120625 Latest Revision: 20211021

20250114

PMC3299859

10.1007/s00335-011-9368-9

22101863