The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation.

Publisher: Blackwell Country of Publication: England NLM ID: 7702118 Publication Model: Print Cited Medium: Internet ISSN: 1600-065X (Electronic) Linking ISSN: 01052896 NLM ISO Abbreviation: Immunol Rev Subsets: MEDLINE

Publication: <2002-> : Oxford : Blackwell
Original Publication: Copenhagen, Munksgaard.

Immunity, Innate* ; Receptors, Tumor Necrosis Factor, Member 14*/genetics ; Receptors, Tumor Necrosis Factor, Member 14*/immunology ; Receptors, Tumor Necrosis Factor, Member 14*/metabolism; Herpes Simplex/*immunology ; Herpesvirus 1, Human/*immunology ; Lymphotoxin-alpha/*immunology ; Signal Transduction/*immunology ; T-Lymphocytes/*immunology ; Tumor Necrosis Factor Ligand Superfamily Member 14/*immunology; Animals ; Antigens, CD/genetics ; Antigens, CD/immunology ; Antigens, CD/metabolism ; Autoimmunity ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/immunology ; GPI-Linked Proteins/metabolism ; Gene Expression/immunology ; Herpes Simplex/metabolism ; Herpes Simplex/virology ; Humans ; Lymphocyte Activation ; Lymphotoxin beta Receptor/genetics ; Lymphotoxin beta Receptor/immunology ; Lymphotoxin beta Receptor/metabolism ; Lymphotoxin-alpha/genetics ; Lymphotoxin-alpha/metabolism ; Mice ; Mice, Knockout ; Protein Binding/immunology ; Receptor Cross-Talk/immunology ; Receptors, Immunologic/genetics ; Receptors, Immunologic/immunology ; Receptors, Immunologic/metabolism ; T-Lymphocytes/metabolism ; Tumor Necrosis Factor Ligand Superfamily Member 14/genetics ; Tumor Necrosis Factor Ligand Superfamily Member 14/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/immunology ; Tumor Necrosis Factor-alpha/metabolism ; Viral Envelope Proteins/immunology ; Viral Envelope Proteins/metabolism

The tumor necrosis factor (TNF) receptor superfamily member herpesvirus entry mediator (HVEM) (TNFRSF14) regulates T-cell immune responses by activating both inflammatory and inhibitory signaling pathways. HVEM acts as both a receptor for the canonical TNF-related ligands, LIGHT [lymphotoxin-like, exhibits inducible expression, and competes with herpes simplex virus glycoprotein D for HVEM, a receptor expressed on T lymphocytes] and lymphotoxin-α, and as a ligand for the immunoglobulin superfamily proteins BTLA (B and T lymphocyte attenuator) and CD160, a feature distinguishing HVEM from other immune regulatory molecules. The ability of HVEM to interact with multiple ligands in distinct configurations creates a functionally diverse set of intrinsic and bidirectional signaling pathways that control both inflammatory and inhibitory responses. The HVEM system is integrated into the larger LTβR and TNFR network through extensive shared ligand and receptor usage. Experimental mouse models and human diseases indicate that dysregulation of HVEM network may contribute to autoimmune pathogenesis, making it an attractive target for drug intervention.
(© 2011 John Wiley & Sons A/S.)

Int Immunol. 2008 Aug;20(8):1067-75. (PMID: 18562337)
J Exp Med. 2002 Jun 17;195(12):1613-24. (PMID: 12070288)
Trends Biochem Sci. 2002 Jan;27(1):19-26. (PMID: 11796220)
Immunity. 2002 Mar;16(3):479-92. (PMID: 11911831)
Nat Immunol. 2008 Feb;9(2):176-85. (PMID: 18193050)
Obesity (Silver Spring). 2010 Feb;18(2):239-46. (PMID: 19680232)
J Immunol. 2010 Jan 1;184(1):127-33. (PMID: 19949073)
PLoS One. 2011 Apr 18;6(4):e18495. (PMID: 21533159)
Annu Rev Immunol. 2005;23:787-819. (PMID: 15771586)
J Immunol. 2009 Feb 1;182(3):1509-17. (PMID: 19155498)
Biochem Pharmacol. 2011 Apr 1;81(7):838-47. (PMID: 21295012)
J Exp Med. 2003 Sep 15;198(6):963-9. (PMID: 12963696)
Immunol Cell Biol. 2007 Nov-Dec;85(8):590-5. (PMID: 17607320)
Biochem Biophys Res Commun. 2006 Jul 14;345(4):1440-5. (PMID: 16725108)
Semin Immunol. 2001 Jun;13(3):163-76. (PMID: 11394959)
Immunol Rev. 2005 Apr;204:144-55. (PMID: 15790356)
J Clin Invest. 2001 Dec;108(12):1771-80. (PMID: 11748260)
Virology. 2006 Jan 5;344(1):17-24. (PMID: 16364731)
Hum Mol Genet. 2009 Nov 1;18(21):4195-203. (PMID: 19648290)
Cell Microbiol. 2004 May;6(5):401-10. (PMID: 15056211)
J Immunol. 1999 Feb 1;162(3):1223-6. (PMID: 9973372)
Biochem Pharmacol. 2003 Feb 15;65(4):657-67. (PMID: 12566095)
Int J Cancer. 2003 Jul 10;105(5):724-32. (PMID: 12740925)
J Clin Invest. 2005 Mar;115(3):711-7. (PMID: 15696194)
J Immunol. 2008 Sep 1;181(5):2973-9. (PMID: 18713967)
J Immunol. 2005 Nov 15;175(10):6420-7. (PMID: 16272294)
J Immunol. 2004 Nov 1;173(9):5349-54. (PMID: 15494480)
FEBS Lett. 2011 Feb 4;585(3):579-84. (PMID: 21236258)
Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6244-9. (PMID: 19332782)
Nat Med. 2011 May;17(5):596-603. (PMID: 21499267)
Blood. 2007 May 1;109(9):4097-104. (PMID: 17179227)
J Leukoc Biol. 2009 Jul;86(1):41-51. (PMID: 19383625)
J Immunol. 2004 Jul 1;173(1):251-8. (PMID: 15210782)
J Immunol. 2009 Mar 1;182(5):3139-45. (PMID: 19234211)
J Biol Chem. 2000 May 12;275(19):14307-15. (PMID: 10799510)
Cell Microbiol. 2008 Nov;10(11):2297-311. (PMID: 18671825)
J Immunol. 2007 May 15;178(10):6073-82. (PMID: 17475832)
J Immunol. 2005 Jun 15;174(12):8173-82. (PMID: 15944326)
Cell Host Microbe. 2007 Jul 12;2(1):19-28. (PMID: 18005714)
J Immunol. 2009 Apr 15;182(8):4516-20. (PMID: 19342624)
J Biol Chem. 1999 May 14;274(20):13733-6. (PMID: 10318773)
J Biol Chem. 1997 May 30;272(22):14029-32. (PMID: 9162022)
Nat Immunol. 2007 Feb;8(2):162-71. (PMID: 17206146)
J Immunol. 2001 Nov 1;167(9):5122-8. (PMID: 11673523)
J Immunol. 2009 Dec 15;183(12):7842-50. (PMID: 19923459)
J Immunol. 2005 Mar 15;174(6):3377-85. (PMID: 15749870)
Nat Immunol. 2004 Feb;5(2):141-9. (PMID: 14704792)
J Immunol. 2010 May 15;184(10):5475-84. (PMID: 20410485)
J Invest Dermatol. 2007 May;127(5):1161-6. (PMID: 17218942)
J Neurosci. 2009 Feb 11;29(6):1599-607. (PMID: 19211867)
Cell Mol Life Sci. 2008 Jun;65(11):1653-68. (PMID: 18351291)
Nat Genet. 2010 Apr;42(4):295-302. (PMID: 20190752)
Nat Immunol. 2003 Jul;4(7):670-9. (PMID: 12796776)
FEBS J. 2009 Dec;276(24):7228-36. (PMID: 19878306)
J Immunol. 2010 Aug 1;185(3):1949-58. (PMID: 20592286)
Cytokine Growth Factor Rev. 2008 Jun-Aug;19(3-4):277-84. (PMID: 18511331)
J Leukoc Biol. 2006 Feb;79(2):330-8. (PMID: 16275888)
J Clin Invest. 2001 Dec;108(12):1741-2. (PMID: 11748255)
J Exp Med. 2004 Apr 19;199(8):1143-51. (PMID: 15078896)
Nat Med. 2008 Feb;14(2):205-12. (PMID: 18193057)
Structure. 2011 Feb 9;19(2):162-71. (PMID: 21300286)
Cell. 1993 Mar 26;72(6):847-56. (PMID: 7916655)
Blood. 2010 Apr 15;115(15):3079-88. (PMID: 20164468)
Blood. 2011 Feb 24;117(8):2506-14. (PMID: 21220749)
Blood. 2006 Feb 15;107(4):1342-51. (PMID: 16223768)
J Immunol. 2009 Jan 1;182(1):63-71. (PMID: 19109136)
J Immunol. 2008 Jan 15;180(2):940-7. (PMID: 18178834)
Eur J Immunol. 2006 Aug;36(8):2215-22. (PMID: 16856205)
J Virol. 2003 Aug;77(16):8985-99. (PMID: 12885915)
J Leukoc Biol. 2011 Apr;89(4):517-23. (PMID: 21106644)
Biochem Biophys Res Commun. 2003 Dec 26;312(4):1236-43. (PMID: 14652006)
J Immunol. 2004 May 15;172(10):5931-9. (PMID: 15128774)
J Immunol. 2006 Apr 1;176(7):3909-13. (PMID: 16547224)
J Cell Physiol. 2006 Dec;209(3):735-43. (PMID: 16972254)
J Immunol. 2007 Feb 1;178(3):1293-300. (PMID: 17237375)
J Clin Invest. 2010 Jan;120(1):76-80. (PMID: 20038807)
Blood. 2002 Nov 1;100(9):3279-86. (PMID: 12384428)
Rev Med Virol. 2007 Sep-Oct;17(5):313-26. (PMID: 17573668)
Cell. 1996 Nov 1;87(3):427-36. (PMID: 8898196)
J Clin Invest. 2010 Jan;120(1):157-67. (PMID: 20038811)
J Exp Med. 1993 Sep 1;178(3):1121-6. (PMID: 7688788)
Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13218-23. (PMID: 16131544)
Cell. 1993 Jul 16;74(1):185-95. (PMID: 7687523)
J Immunol. 2008 Jan 1;180(1):238-48. (PMID: 18097025)
Trends Immunol. 2006 Aug;27(8):362-7. (PMID: 16807107)
J Immunol. 2005 Jan 15;174(2):646-53. (PMID: 15634882)
J Exp Med. 2010 Nov 22;207(12):2551-9. (PMID: 21078889)
J Immunol. 2009 Dec 1;183(11):7286-96. (PMID: 19915044)
Biochem Biophys Res Commun. 2006 Jun 16;344(4):1121-7. (PMID: 16643847)
Virology. 2004 May 1;322(2):286-99. (PMID: 15110526)
Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1116-21. (PMID: 15647361)
Arthritis Rheum. 2008 Aug;58(8):2498-510. (PMID: 18668554)
PLoS One. 2011 Jan 24;6(1):e16122. (PMID: 21283640)
J Biol Chem. 1988 Sep 15;263(26):12816-9. (PMID: 3417634)
Transplantation. 2007 Sep 27;84(6):746-54. (PMID: 17893608)
Cell. 2001 Feb 23;104(4):487-501. (PMID: 11239407)
Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16963-8. (PMID: 12486241)
Rev Med Virol. 2007 May-Jun;17(3):205-15. (PMID: 17295428)
J Biol Chem. 2002 Nov 8;277(45):42841-51. (PMID: 12215452)
Mol Cell. 2001 Jul;8(1):169-79. (PMID: 11511370)
World J Gastroenterol. 2005 Oct 14;11(38):5926-30. (PMID: 16273601)
J Immunol. 2008 May 15;180(10):6649-55. (PMID: 18453584)
Ups J Med Sci. 2008;113(3):297-304. (PMID: 18991242)
Nature. 1998 Dec 17;396(6712):699-703. (PMID: 9872321)
J Immunol. 2009 Aug 1;183(3):1946-51. (PMID: 19587015)
J Exp Med. 2002 Mar 18;195(6):795-800. (PMID: 11901205)
Nat Immunol. 2005 Jan;6(1):90-8. (PMID: 15568026)
Annu Rev Immunol. 2010;28:389-411. (PMID: 20307212)
J Immunol. 2007 Sep 15;179(6):4093-100. (PMID: 17785848)
J Immunol. 2005 Oct 1;175(7):4426-32. (PMID: 16177084)
Blood. 2011 Aug 25;118(8):2174-83. (PMID: 21715317)
J Exp Med. 2011 Apr 11;208(4):797-809. (PMID: 21402741)
J Immunol. 2009 Jul 1;183(1):32-6. (PMID: 19535622)
J Biol Chem. 1997 May 23;272(21):13471-4. (PMID: 9153189)
J Biol Chem. 2005 Nov 25;280(47):39553-61. (PMID: 16169851)
J Immunol. 2006 Jun 1;176(11):6603-14. (PMID: 16709818)
J Immunol. 2001 Dec 1;167(11):6330-7. (PMID: 11714797)
Nat Rev Immunol. 2008 Nov;8(11):861-73. (PMID: 18949019)
J Immunol. 2007 Nov 1;179(9):6305-10. (PMID: 17947707)
Mod Rheumatol. 2010 Feb;20(1):63-8. (PMID: 19821006)
J Exp Med. 2008 Jun 9;205(6):1463-76. (PMID: 18519647)
Semin Immunopathol. 2009 Jul;31(2):207-21. (PMID: 19495760)
Tissue Antigens. 2007 Feb;69(2):145-53. (PMID: 17257317)
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17916-20. (PMID: 19805039)

AI067890 United States AI NIAID NIH HHS; R21 AI088445 United States AI NIAID NIH HHS; R01 AI067890 United States AI NIAID NIH HHS; R37AI33068 United States AI NIAID NIH HHS; R01 AI048074 United States AI NIAID NIH HHS; R01 AI048073 United States AI NIAID NIH HHS; R37 AI033068 United States AI NIAID NIH HHS; AI048074 United States AI NIAID NIH HHS

0 (Antigens, CD)
0 (CD160 protein, human)
0 (GPI-Linked Proteins)
0 (Lymphotoxin beta Receptor)
0 (Lymphotoxin-alpha)
0 (Receptors, Immunologic)
0 (Receptors, Tumor Necrosis Factor, Member 14)
0 (TNFRSF14 protein, human)
0 (Tumor Necrosis Factor Ligand Superfamily Member 14)
0 (Tumor Necrosis Factor-alpha)
0 (Viral Envelope Proteins)
0 (glycoprotein D, Human herpesvirus 1)

Date Created: 20111025 Date Completed: 20120209 Latest Revision: 20240610

20240610

PMC3381650

10.1111/j.1600-065X.2011.01064.x

22017438