Motor antagonism exposed by spatial segregation and timing of neurogenesis.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

Publication: Basingstoke : Nature Publishing Group
Original Publication: London, Macmillan Journals ltd.

Motor Neurons/*cytology ; Motor Neurons/*physiology ; Neurogenesis/*physiology ; Walking/*physiology; Animals ; Extremities/innervation ; Extremities/physiology ; Female ; Interneurons/cytology ; Interneurons/metabolism ; Male ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Muscle, Skeletal/cytology ; Muscle, Skeletal/innervation ; Muscle, Skeletal/physiology ; Nerve Net/cytology ; Nerve Net/physiology ; Neuroanatomical Tract-Tracing Techniques ; Proprioception/physiology ; Spinal Cord/cytology ; Spinal Cord/physiology ; Synapses/metabolism ; Time Factors

Walking is a key motor behaviour of limbed animals, executed by contraction of functionally antagonistic muscle groups during swing and stance phases. Nevertheless, neuronal circuits regulating the activation of antagonistic extensor-flexor muscles remain poorly understood. Here we use monosynaptically restricted trans-synaptic viruses to elucidate premotor anatomical substrates for extensor-flexor control in mice. We observe a medio-lateral spatial segregation between extensor and flexor premotor interneurons in the dorsal spinal cord. These premotor interneuron populations are derived from common progenitor domains, but segregate by timing of neurogenesis. We find that proprioceptive sensory feedback from the periphery is targeted to medial extensor premotor populations and is required for extensor-specific connectivity profiles during development. Our findings provide evidence for a discriminating anatomical basis of antagonistic circuits at the level of premotor interneurons, and point to synaptic input and developmental ontogeny as key factors in the establishment of circuits regulating motor behavioural dichotomy.

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Date Created: 20111021 Date Completed: 20120125 Latest Revision: 20211020

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