Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction: a double-blinded, prospective, randomized, controlled trial.

Publisher: Springer International for the Japan Society of Anesthesiology Country of Publication: Japan NLM ID: 8905667 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1438-8359 (Electronic) Linking ISSN: 09138668 NLM ISO Abbreviation: J Anesth Subsets: MEDLINE

Publication: Tokyo : Springer International for the Japan Society of Anesthesiology
Original Publication: [Tokyo] : Japan Society of Anesthesiology, [1987-

Anesthetics, Intravenous/*adverse effects ; Bridged Bicyclo Compounds, Heterocyclic/*therapeutic use ; Cough/*chemically induced ; Cough/*drug therapy ; Fentanyl/*adverse effects ; Tetrahydronaphthalenes/*therapeutic use; Anesthesia, General/methods ; Anesthetics, Intravenous/administration & dosage ; Double-Blind Method ; Drug Interactions ; Female ; Fentanyl/administration & dosage ; Humans ; Male ; Middle Aged

Purpose: To evaluate the suppressive effect of intravenous dezocine on fentanyl-induced cough during the induction of general anesthesia.
Methods: A total of 120 patients, American Society of Anesthesiologists (ASA) physical status I-II, were randomized into two equally sized groups (n = 60). These two groups were given either intravenous dezocine 0.1 mg/kg or a matching placebo (equal volume of 0.9% saline) 10 min before the induction of general anesthesia. Patients were induced with midazolam 0.1 mg/kg, fentanyl 5 μg/kg, propofol 1-1.5 mg/kg, and suxamethonium 1.5 mg/kg. The injection time of fentanyl was less than 2 s in all patients. The occurrence of cough was recorded 2 min after fentanyl bolus.
Results: No patient in the dezocine group had cough, and 42 patients in the control group had cough. This difference was statistically different between these two groups (P = 0.000).
Conclusion: These results demonstrate that intravenous dezocine 0.1 mg/kg 10 min prior to induction was effective in suppressing fentanyl-induced cough in our patients.

Comment in: J Anesth. 2012 Jun;26(3):470. doi: 10.1007/s00540-011-1318-x. (PMID: 22228499)

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0 (Anesthetics, Intravenous)
0 (Bridged Bicyclo Compounds, Heterocyclic)
0 (Tetrahydronaphthalenes)
UF599785JZ (Fentanyl)
VHX8K5SV4X (dezocine)

Date Created: 20110922 Date Completed: 20120627 Latest Revision: 20211020

20250114

10.1007/s00540-011-1237-x

21935685