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Clinicopathological features of hepatosplenic T cell lymphoma: a single centre experience from India.

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  • معلومة اضافية
    • المصدر:
      Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2403 (Electronic) Linking ISSN: 10268022 NLM ISO Abbreviation: Leuk Lymphoma Subsets: MEDLINE
    • بيانات النشر:
      Publication: [Philadelphia, PA] : Taylor & Francis
      Original Publication: Chur ; New York : London, UK : Harwood Academic Publishers ; Distributed by STBS, 1989-
    • الموضوع:
      Liver Neoplasms/*pathology ; Lymphoma, T-Cell/*pathology ; Splenic Neoplasms/*pathology; Adolescent ; Adult ; Antigens, CD/metabolism ; Chromosome Aberrations ; Chromosomes, Human, Pair 7/genetics ; Fatal Outcome ; Female ; Flow Cytometry ; Humans ; Immunophenotyping ; In Situ Hybridization, Fluorescence ; India ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Lymphoma, T-Cell/genetics ; Lymphoma, T-Cell/metabolism ; Male ; Middle Aged ; Splenic Neoplasms/genetics ; Splenic Neoplasms/metabolism ; Young Adult
    • نبذة مختصرة :
      In a first series from India, we report 9 cases of hepatosplenic T cell lymphoma (HSTCL) seen in 23 months accounting for 4.2% of all mature T-non-Hodgkin lymphomas (NHLs) in our institution. All patients presented with organomegaly, cytopenias and had evidence of bone marrow involvement. The tumor cells had a blastic (55%) morphology with predominantly intrasinusoidal (33.3%) or intrasinusoidal with an additional interstitial component (33.3%). On flow cytometry, the classical phenotype (CD3+, CD7+, CD4-, CD8-, CD5-, CD56+/-) was seen only in 4 patients. Unusual variations included CD45 (overexpression), CD7 (dim expression), CD3 (overexpression, heterogeneous and dim), CD2 (overexpression), CD5 (heterogeneous), CD8 (heterogeneous or dim or overexpression) and aberrant expression of CD19. Fluoresvent in situ hybridisation (FISH) and karyotyping was abnormal in 5 out of 7 patients evaluated. All of the 5 cases showed abnormalities in chromosome 7 (ring chromosome or isochromosome 7q). Five patients died of disease and related complications in a span of 1-3 months after diagnosis whereas 4 were alive at their last follow up out of which 2 had documented a relapse. In our series, HSTCL was characterized by typical clinical and variable immunophenotypic features and a dismal clinical outcome.
    • الرقم المعرف:
      0 (Antigens, CD)
    • الموضوع:
      Date Created: 20110916 Date Completed: 20120823 Latest Revision: 20190116
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.3109/10428194.2011.622421
    • الرقم المعرف:
      21916832