Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Serum levels of advanced glycation end products (AGEs) are inversely associated with the number and migratory activity of circulating endothelial progenitor cells in apparently healthy subjects.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Hindawi Country of Publication: England NLM ID: 101319630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-5922 (Electronic) Linking ISSN: 17555914 NLM ISO Abbreviation: Cardiovasc Ther Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2019- : [London, United Kingdom] : Hindawi
      Original Publication: Oxford : Wiley-Blackwell, c2008-c2018.
    • الموضوع:
      Atherosclerosis/*blood ; Endothelial Cells/*metabolism ; Glycation End Products, Advanced/*blood ; Stem Cells/*metabolism; Adult ; Antigens, CD34/blood ; Biomarkers/blood ; Cell Count ; Cell Movement ; Cells, Cultured ; Chi-Square Distribution ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Female ; Flow Cytometry ; Humans ; Japan ; Logistic Models ; Male ; Multivariate Analysis ; Sex Factors ; Smoking/blood ; Vascular Endothelial Growth Factor Receptor-2/blood
    • نبذة مختصرة :
      Objectives: Endothelial progenitor cells (EPCs) have been shown to participate in the process of vascular repair, thus playing a protective role against cardiovascular disease (CVD). It is known that atherosclerotic risk factors could affect EPC number and function. Advanced glycation end products (AGEs) contribute to the pathogenesis of atherosclerosis as well. However, as far as we know, there is no report to show the relationship between serum AGE levels and circulating EPCs in humans. Therefore, in this study, we investigated whether serum level of AGEs was associated with EPC number and functions in apparently healthy subjects, independent of traditional cardiovascular risk factors.
      Research Design and Methods: Apparently healthy volunteers (34.6 ± 6.9 years old, 40 males and 8 females) who were not on any medications underwent a complete history and physical examination, determination of blood chemistries, including AGEs, and number, differentiation and migratory activity of circulating EPCs.
      Results: Serum AGEs levels were 9.20 ± 1.85 U/mL. Multiple stepwise regression analysis revealed that serum levels of AGEs and smoking were independently correlated with reduced number of EPCs. Further, female, AGEs, and reduced HDL-cholesterol levels were independently associated with impaired migratory activity of circulating EPCs.
      Conclusions: This study demonstrated for the first time that the serum level of AGEs was one of the independent correlates of decreased cell number and impaired migratory activity of circulating EPCs in apparently healthy subjects. Our present observations suggest that even in young healthy subjects, serum level of AGEs may be a biomarker that could predict the progression of atherosclerosis and future cardiovascular events.
      (© 2011 Blackwell Publishing Ltd.)
    • الرقم المعرف:
      0 (Antigens, CD34)
      0 (Biomarkers)
      0 (Cholesterol, HDL)
      0 (Glycation End Products, Advanced)
      EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2)
    • الموضوع:
      Date Created: 20110903 Date Completed: 20121113 Latest Revision: 20171116
    • الموضوع:
      20221213
    • الرقم المعرف:
      10.1111/j.1755-5922.2011.00264.x
    • الرقم المعرف:
      21884000