Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Feau S;Feau S; Arens R; Togher S; Schoenberger SP
  • المصدر:
    Nature immunology [Nat Immunol] 2011 Jul 31; Vol. 12 (9), pp. 908-13. Date of Electronic Publication: 2011 Jul 31.
  • نوع النشر :
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: New York, NY : Nature America Inc. c2000-
    • الموضوع:
      Autocrine Communication* ; CD8-Positive T-Lymphocytes*/cytology ; CD8-Positive T-Lymphocytes*/immunology ; CD8-Positive T-Lymphocytes*/metabolism ; Immunologic Memory*; CD4-Positive T-Lymphocytes/*immunology ; CD40 Antigens/*immunology ; CD40 Ligand/*immunology ; Dendritic Cells/*immunology ; Interleukin-2/*immunology; Animals ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/metabolism ; CD40 Antigens/metabolism ; CD40 Ligand/metabolism ; Cell Proliferation ; Dendritic Cells/cytology ; Dendritic Cells/metabolism ; Flow Cytometry ; Interleukin-2/metabolism ; Listeria monocytogenes/growth & development ; Listeriosis/immunology ; Listeriosis/microbiology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction/immunology
    • نبذة مختصرة :
      Two competing theories have been put forward to explain the role of CD4(+) T cells in priming CD8(+) memory T cells: one proposes paracrine secretion of interleukin 2 (IL-2); the other proposes the activation of antigen-presenting cells (APCs) via the costimulatory molecule CD40 and its ligand CD40L. We investigated the requirement for IL-2 by the relevant three cell types in vivo and found that CD8(+) T cells, rather than CD4(+) T cells or dendritic cells (DCs), produced the IL-2 necessary for CD8(+) T cell memory. Il2(-/-) CD4(+) T cells were able to provide help only if their ability to transmit signals via CD40L was intact. Our findings reconcile contradictory elements implicit in each model noted above by showing that CD4(+) T cells activate APCs through a CD40L-dependent mechanism to enable autocrine production of IL-2 in CD8(+) memory T cells.
    • References:
      Science. 1996 Apr 5;272(5258):54-60. (PMID: 8600537)
      Nature. 1998 Jun 4;393(6684):478-80. (PMID: 9624004)
      Science. 1993 Nov 12;262(5136):1059-61. (PMID: 8235625)
      Nature. 1998 Jun 4;393(6684):474-8. (PMID: 9624003)
      Immunol Rev. 1995 Dec;148:35-44. (PMID: 8825281)
      Nature. 1991 Aug 15;352(6336):621-4. (PMID: 1830926)
      J Exp Med. 1997 Dec 15;186(12):2057-62. (PMID: 9396776)
      Immunity. 2011 Feb 25;34(2):224-36. (PMID: 21295499)
      J Exp Med. 2004 Aug 2;200(3):287-95. (PMID: 15289500)
      Science. 2003 Apr 11;300(5617):337-9. (PMID: 12690201)
      Eur J Immunol. 1987 Nov;17(11):1579-83. (PMID: 2445585)
      Nature. 2006 Jun 15;441(7095):890-3. (PMID: 16778891)
      Science. 2002 Sep 20;297(5589):2060-3. (PMID: 12242444)
      Curr Opin Immunol. 2004 Apr;16(2):217-25. (PMID: 15023416)
      Nature. 2006 Apr 13;440(7086):890-5. (PMID: 16612374)
      Cancer Res. 2000 Jun 15;60(12):3239-46. (PMID: 10866317)
      Nat Rev Immunol. 2004 Sep;4(9):665-74. (PMID: 15343366)
      J Immunol. 2003 Dec 1;171(11):5727-35. (PMID: 14634080)
      Immunity. 2010 Jan 29;32(1):79-90. (PMID: 20096607)
      Immunol Cell Biol. 2000 Apr;78(2):110-7. (PMID: 10762410)
      Immunity. 2007 Jun;26(6):827-41. (PMID: 17555991)
      Science. 2003 Apr 11;300(5617):339-42. (PMID: 12690202)
      J Immunol. 2003 May 15;170(10):5075-81. (PMID: 12734352)
      J Exp Med. 1996 Sep 1;184(3):923-30. (PMID: 9064352)
      Nature. 2005 Mar 3;434(7029):88-93. (PMID: 15744305)
      Nature. 1990 Mar 1;344(6261):65-7. (PMID: 2304556)
      Nat Immunol. 2001 May;2(5):423-9. (PMID: 11323696)
      Nature. 2003 Feb 20;421(6925):852-6. (PMID: 12594515)
      J Immunol. 2008 Dec 1;181(11):7445-8. (PMID: 19017930)
      Nature. 1998 Jun 4;393(6684):413-4. (PMID: 9623994)
      Immunity. 2010 Jan 29;32(1):91-103. (PMID: 20096608)
      J Exp Med. 1982 Mar 1;155(3):768-82. (PMID: 6801178)
      Am J Transplant. 2003 Nov;3(11):1355-62. (PMID: 14525595)
      Nature. 1998 Jun 4;393(6684):480-3. (PMID: 9624005)
      Nat Immunol. 2003 Apr;4(4):361-5. (PMID: 12640451)
      Eur J Immunol. 1995 Nov;25(11):3053-9. (PMID: 7489743)
      J Immunol. 2001 Jul 15;167(2):741-8. (PMID: 11441078)
      Nat Immunol. 2002 Jul;3(7):619-26. (PMID: 12055624)
      J Immunol. 2006 Jul 15;177(2):999-1006. (PMID: 16818756)
      Nat Immunol. 2001 May;2(5):415-22. (PMID: 11323695)
    • Grant Information:
      R01 AI076972 United States AI NIAID NIH HHS; R01 CA081261 United States CA NCI NIH HHS; R01CA81261 United States CA NCI NIH HHS
    • الرقم المعرف:
      0 (CD40 Antigens)
      0 (Interleukin-2)
      147205-72-9 (CD40 Ligand)
    • الموضوع:
      Date Created: 20110802 Date Completed: 20111108 Latest Revision: 20211020
    • الموضوع:
      20221213
    • الرقم المعرف:
      PMC3388550
    • الرقم المعرف:
      10.1038/ni.2079
    • الرقم المعرف:
      21804558