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Apoptosis and other cell death mechanisms after retinal detachment: implications for photoreceptor rescue.

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  • المؤلفون: Lo AC;Lo AC; Woo TT; Wong RL; Wong D
  • المصدر:
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde [Ophthalmologica] 2011; Vol. 226 Suppl 1, pp. 10-7. Date of Electronic Publication: 2011 Jul 22.
  • نوع النشر :
    Journal Article; Review
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Karger Country of Publication: Switzerland NLM ID: 0054655 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0267 (Electronic) Linking ISSN: 00303755 NLM ISO Abbreviation: Ophthalmologica Subsets: MEDLINE
    • بيانات النشر:
      Publication: Basel : Karger
      Original Publication: Basel.
    • الموضوع:
      Apoptosis* ; Necrosis*; Photoreceptor Cells, Vertebrate/*pathology ; Retinal Detachment/*pathology; Cell Survival/physiology ; Cytoprotection/physiology ; Humans
    • نبذة مختصرة :
      Retinal detachment (RD) is one of the most common causes of blindness. This separation of the neurosensory retina from its underlying retinal pigment epithelium results in photoreceptor loss, which is the basis of permanent visual impairment. This review explores the various cell death mechanisms in photoreceptor death associated with RD. One of the major mechanisms is apoptosis, mediated by the intrinsic pathway, the Fas signalling pathway and/or the caspase-independent pathway. Other pathways of mechanisms include endoplasmic reticulum stress-mediated cell death, programmed necrosis and cytokine-related pathways. Understanding the mechanism of RD-associated photoreceptor death is likely to help us improve the current therapies or devise new strategies for this sight-threatening condition.
      (Copyright © 2011 S. Karger AG, Basel.)
    • الموضوع:
      Date Created: 20110723 Date Completed: 20110930 Latest Revision: 20110722
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.1159/000328206
    • الرقم المعرف:
      21778775