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Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children.

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  • المؤلفون: Martin ET;Martin ET; Kuypers J; Wald A; Englund JA
  • المصدر:
    Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2012 Jan; Vol. 6 (1), pp. 71-7. Date of Electronic Publication: 2011 May 31.
  • نوع النشر :
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Wiley Country of Publication: England NLM ID: 101304007 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2659 (Electronic) Linking ISSN: 17502640 NLM ISO Abbreviation: Influenza Other Respir Viruses Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Oxford, UK : Wiley, c2007-
    • الموضوع:
      Severity of Illness Index* ; Viral Load*; Coinfection/*epidemiology ; Respiratory Tract Infections/*epidemiology ; Virus Diseases/*epidemiology ; Viruses/*classification ; Viruses/*isolation & purification; Adolescent ; Child ; Child, Hospitalized ; Child, Preschool ; Coinfection/pathology ; Coinfection/virology ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Nasal Cavity/virology ; Nasal Lavage Fluid ; Respiratory Tract Infections/pathology ; Respiratory Tract Infections/virology ; Virus Diseases/pathology ; Virus Diseases/virology ; Washington/epidemiology ; Young Adult
    • نبذة مختصرة :
      Background: Molecular testing for viral pathogens has resulted in increasing detection of multiple viruses in respiratory secretions of ill children. The clinical impact of multiple virus infections on clinical presentation and outcome is unclear.
      Objectives: To compare clinical characteristics and viral load between children with multiple virus versus single virus illnesses.
      Patients/methods: Eight hundred and ninety-three residual nasal wash samples from children treated for respiratory illness at Children's Hospital, Seattle, from September 2003 to September 2004 were evaluated by quantitative PCR for respiratory syncytial virus (RSV), human metapneumovirus (hMPV), influenza (Flu), parainfluenza, adenoviruses, and coronaviruses (CoV). Illness severity and patient characteristics were abstracted from medical charts.
      Results: Coinfections were identified in 103 (18%) of 566 virus-positive samples. Adenovirus was most commonly detected in coinfections (52%), followed by CoV (50%). Illnesses with a single virus had increased risk of oxygen requirement (P = 0·02), extended hospital stays (P = 0·002), and admissions to the inpatient (P = 0·02) or intensive care units (P = 0·04). For Adv and PIV-1, multiple virus illnesses had a significantly lower viral load (log(10) copies/ml) than single virus illnesses (4·2 versus 5·6, P = 0·007 and 4·2 versus 6·9, P < 0·001, respectively). RSV, Flu-A, PIV-3, and hMPV viral loads were consistently high whether or not another virus was detected.
      Conclusions: Illnesses with multiple virus detections were correlated with less severe disease. The relationship between viral load and multiple virus infections was virus specific, and this may serve as a way to differentiate viruses in multiple virus infections.
      (© 2011 Blackwell Publishing Ltd.)
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    • Grant Information:
      K24 AI071113 United States AI NIAID NIH HHS; K24 AI071113-06 United States AI NIAID NIH HHS; K24 AI 071113 United States AI NIAID NIH HHS
    • الموضوع:
      Date Created: 20110615 Date Completed: 20120329 Latest Revision: 20220310
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC3175338
    • الرقم المعرف:
      10.1111/j.1750-2659.2011.00265.x
    • الرقم المعرف:
      21668660