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The OBELIX project: early life exposure to endocrine disruptors and obesity.

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  • معلومة اضافية
    • المصدر:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0376027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-3207 (Electronic) Linking ISSN: 00029165 NLM ISO Abbreviation: Am J Clin Nutr Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2023- : [New York, NY] : Elsevier
      Original Publication: Bethesda, MD : American Society of Clinical Nutrition
    • الموضوع:
      Endocrine Disruptors/*toxicity ; Environmental Exposure/*adverse effects ; Obesity/*epidemiology ; Obesity/*etiology ; Polychlorinated Biphenyls/*toxicity; Animals ; Biomarkers ; Child ; Child Nutritional Physiological Phenomena ; Child, Preschool ; Cohort Studies ; Disease Models, Animal ; Europe ; Female ; Flame Retardants/toxicity ; Follow-Up Studies ; Food Contamination/analysis ; Humans ; Male ; Maternal Exposure ; Mice ; Milk, Human/chemistry ; Pesticides/toxicity ; Risk Assessment ; Risk Factors
    • نبذة مختصرة :
      The hypothesis of whether early life exposure (both pre- and early postnatal) to endocrine-disrupting chemicals (EDCs) may be a risk factor for obesity and related metabolic diseases later in life will be tested in the European research project OBELIX (OBesogenic Endocrine disrupting chemicals: LInking prenatal eXposure to the development of obesity later in life). OBELIX is a 4-y project that started in May 2009 and which has the following 5 main objectives: 1) to assess early life exposure in humans to major classes of EDCs identified as potential inducers of obesity (ie, dioxin-like compounds, non-dioxin-like polychlorinated biphenyls, organochlorine pesticides, brominated flame retardants, phthalates, and perfluorinated compounds) by using mother-child cohorts from 4 European regions with different food-contaminant exposure patterns; 2) to relate early life exposure to EDCs with clinical markers, novel biomarkers, and health-effect data related to obesity; 3) to perform hazard characterization of early life exposure to EDCs for the development of obesity later in life by using a mouse model; 4) to determine mechanisms of action of obesogenic EDCs on developmental programming with in vivo and in vitro genomics and epigenetic analyses; and 5) to perform risk assessments of prenatal exposure to obesogenic EDCs in food by integrating maternal exposure through food-contaminant exposure and health-effect data in children and hazard data in animal studies.
    • الرقم المعرف:
      0 (Biomarkers)
      0 (Endocrine Disruptors)
      0 (Flame Retardants)
      0 (Pesticides)
      DFC2HB4I0K (Polychlorinated Biphenyls)
    • الموضوع:
      Date Created: 20110506 Date Completed: 20120213 Latest Revision: 20230318
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.3945/ajcn.110.001669
    • الرقم المعرف:
      21543539