Interaction between serum uric acid and triglycerides in relation to blood pressure.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8811625 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5527 (Electronic) Linking ISSN: 09509240 NLM ISO Abbreviation: J Hum Hypertens Subsets: MEDLINE

Publication: <2003->: London : Nature Publishing Group
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical, Macmillan Press, c1987-

Blood Pressure*; Hyperlipidemias/*epidemiology ; Hypertension/*epidemiology ; Hyperuricemia/*epidemiology ; Obesity/*epidemiology ; Triglycerides/*blood ; Uric Acid/*blood; Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Biomarkers/blood ; Blood Glucose/analysis ; Body Mass Index ; China/epidemiology ; Cholesterol, HDL/blood ; Female ; Health Surveys ; Humans ; Hyperlipidemias/blood ; Hyperlipidemias/physiopathology ; Hypertension/blood ; Hypertension/physiopathology ; Hyperuricemia/blood ; Hyperuricemia/physiopathology ; Logistic Models ; Male ; Middle Aged ; Obesity/blood ; Obesity/physiopathology ; Odds Ratio ; Risk Assessment ; Risk Factors ; Young Adult

The aim of this study was to examine the independent relationship between serum uric acid (SUA) and blood pressure, and to assess their joint effects on obesity, fasting glucose and lipids. The study samples were from a community-based health examination survey in Xuzhou, Jiangsu province of China (2009). Blood pressure, body mass index, fasting glucose, lipids and SUA were measured. After excluding individuals with fasting glucose greater than 7 mmol l(-1), a total of 8415 subjects with biomarkers available were included in the present study. Blood pressure increased with elevated SUA levels, after adjusting for age and sex. Further adjustment for fasting glucose, lipids and alcohol consumption did not change the increasing trend. The associations between uric acid and hypertension were most evident in those with highest quintiles of high-density lipoprotein cholesterol (HDL-C). In addition, the associations were significant in both men and women, and we found significant interactions between uric acid status and age on hypertension. When the joint effects were examined, we found an additive effect of triglycerides and uric acid levels on diastolic blood pressure (DBP). There was significant association between SUA and hypertension, independent of other metabolic risk factors. HDL-C levels may modify the associations between uric acid and hypertension. The effects of triglycerides and uric acid levels on DBP were additive.

0 (Biomarkers)
0 (Blood Glucose)
0 (Cholesterol, HDL)
0 (Triglycerides)
268B43MJ25 (Uric Acid)

Date Created: 20101217 Date Completed: 20120206 Latest Revision: 20220330

20240829

10.1038/jhh.2010.112

21160529