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Mitochondrial tyrosine phosphoproteome: new insights from an up-to-date analysis.

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  • المؤلفون: Cesaro L;Cesaro L; Salvi M
  • المصدر:
    BioFactors (Oxford, England) [Biofactors] 2010 Nov-Dec; Vol. 36 (6), pp. 437-50.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Ios Press Country of Publication: Netherlands NLM ID: 8807441 Publication Model: Print Cited Medium: Internet ISSN: 1872-8081 (Electronic) Linking ISSN: 09516433 NLM ISO Abbreviation: Biofactors Subsets: MEDLINE
    • بيانات النشر:
      Publication: Amsterdam : Ios Press
      Original Publication: Oxford ; Washington, DC : Published for the International Union of Biochemistry by IRL Press, [c1988-
    • الموضوع:
      Mitochondrial Proteins*/chemistry ; Mitochondrial Proteins*/classification ; Mitochondrial Proteins*/metabolism ; Phosphoproteins*/chemistry ; Phosphoproteins*/classification ; Phosphoproteins*/metabolism ; Tyrosine*/chemistry ; Tyrosine*/metabolism; Mitochondria/*metabolism ; Phosphotransferases/*metabolism ; Proteome/*metabolism; Humans ; Models, Molecular ; Phosphorylation
    • نبذة مختصرة :
      Tyrosine phosphorylation is a newcomer in the mitochondrial signaling and is currently emerging as an important mechanism for regulating mitochondrial processes. But to what extent? By analyzing an updated draft of the mitochondrial tyrosine phosphoproteome, the following observations can be drawn: more than a hundred mitochondrial proteins undergo tyrosine phosphorylation, phosphotyrosine proteins are distributed in each of the submitochondrial compartments, and mitochondrial tyrosine phosphorylated proteins are involved in a variety of functions as metabolism (electron transport chain, Krebs cycle, fatty acid and amino acid metabolism), solute and protein transport, mitochondrial translation machinery, quality protein assessment, oxidative stress, apoptosis, fission, and other. This large and varied collection suggests that tyrosine phosphorylation could be a widespread mechanism in modulating mitochondrial functions. Moreover the in silico model is here used to explore potential effects of tyrosine phosphorylation on selected mitochondrial proteins pointing out some future perspectives in this field.
      (© 2010 International Union of Biochemistry and Molecular Biology, Inc.)
    • الرقم المعرف:
      0 (Mitochondrial Proteins)
      0 (Phosphoproteins)
      0 (Proteome)
      42HK56048U (Tyrosine)
      EC 2.7.- (Phosphotransferases)
    • الموضوع:
      Date Created: 20101113 Date Completed: 20110531 Latest Revision: 20131121
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1002/biof.123
    • الرقم المعرف:
      21072759