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Reassortment of ancient neuraminidase and recent hemagglutinin in pandemic (H1N1) 2009 virus.

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  • المؤلفون: Bhoumik P;Bhoumik P; Hughes AL
  • المصدر:
    Emerging infectious diseases [Emerg Infect Dis] 2010 Nov; Vol. 16 (11), pp. 1748-50.
  • نوع النشر :
    Journal Article; Research Support, N.I.H., Extramural
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-
    • الموضوع:
      Pandemics*; Hemagglutinins/*genetics ; Influenza A Virus, H1N1 Subtype/*genetics ; Neuraminidase/*genetics ; Reassortant Viruses/*genetics; Evolution, Molecular ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Viral/physiology ; Humans ; Influenza, Human/epidemiology ; Influenza, Human/virology ; Models, Molecular ; Phylogeny ; Polymorphism, Genetic ; Viral Proteins/chemistry ; Viral Proteins/genetics ; Viral Proteins/metabolism
    • نبذة مختصرة :
      Sequence analyses show that the outbreak of pandemic (H1N1) 2009 resulted from the spread of a recently derived hemagglutinin through a population of ancient and more diverse neuraminidase segments. This pattern implies reassortment and suggests that the novel form of hemagglutinin conferred a selective advantage.
    • Comments:
      Erratum in: Emerg Infect Dis. 2011 Nov;17(11):2180.
    • References:
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    • Grant Information:
      R01 GM043940 United States GM NIGMS NIH HHS; GM43940 United States GM NIGMS NIH HHS
    • الرقم المعرف:
      0 (Hemagglutinins)
      0 (Viral Proteins)
      EC 3.2.1.18 (Neuraminidase)
    • الموضوع:
      Date Created: 20101030 Date Completed: 20110302 Latest Revision: 20211020
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC3294508
    • الرقم المعرف:
      10.3201/eid1611.100361
    • الرقم المعرف:
      21029534