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Epidemiology of methicillin-susceptible Staphylococcus aureus lineages in five major African towns: high prevalence of Panton-Valentine leukocidin genes.
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- معلومة اضافية
- Corporate Authors:
- المصدر:
Publisher: Elsevier Country of Publication: England NLM ID: 9516420 Publication Model: Print Cited Medium: Internet ISSN: 1469-0691 (Electronic) Linking ISSN: 1198743X NLM ISO Abbreviation: Clin Microbiol Infect Subsets: MEDLINE
- بيانات النشر:
Publication: 2015- : London : Elsevier
Original Publication: Paris : Decker Europe, c1995-
- الموضوع:
- نبذة مختصرة :
The epidemiology of methicillin-susceptible Staphylococcus aureus (MSSA) in Africa is poorly documented. From January 2007 to March 2008, 555 S. aureus isolates were collected from five African towns in Cameroon, Madagascar, Morocco, Niger, and Senegal; among these, 456 unique isolates were susceptible to methicillin. Approximately 50% of the MSSA isolates from each different participating centre were randomly selected for further molecular analysis. Of the 228 isolates investigated, 132 (58%) belonged to five major multilocus sequence typing (MLST) clonal complexes (CCs) (CC1, CC15, CC30, CC121 and CC152) that were not related to any successful methicillin-resistant S. aureus (MRSA) clones previously identified in the same study population. The luk-PV genes encoding Panton-Valentine leukocidin (PVL), present in 130 isolates overall (57%), were highly prevalent in isolates from Cameroon, Niger, and Senegal (West and Central Africa). This finding is of major concern, with regard to both a source of severe infections and a potential reservoir for PVL genes. This overrepresentation of PVL in MSSA could lead to the emergence and spread of successful, highly virulent PVL-positive MRSA clones, a phenomenon that has already started in Africa.
(© 2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases.)
- الرقم المعرف:
0 (Anti-Bacterial Agents)
0 (Bacterial Toxins)
0 (Exotoxins)
0 (Leukocidins)
0 (Panton-Valentine leukocidin)
0 (Virulence Factors)
Q91FH1328A (Methicillin)
- الموضوع:
Date Created: 20100803 Date Completed: 20110715 Latest Revision: 20220321
- الموضوع:
20231215
- الرقم المعرف:
10.1111/j.1469-0691.2010.03320.x
- الرقم المعرف:
20673269
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