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Association of the histidine-triad nucleotide-binding protein-1 (HINT1) gene variants with nicotine dependence.

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  • المؤلفون: Jackson KJ;Jackson KJ; Chen Q; Chen J; Aggen SH; Kendler KS; Chen X
  • المصدر:
    The pharmacogenomics journal [Pharmacogenomics J] 2011 Aug; Vol. 11 (4), pp. 251-7. Date of Electronic Publication: 2010 Jun 01.
  • نوع النشر :
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101083949 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-1150 (Electronic) Linking ISSN: 1470269X NLM ISO Abbreviation: Pharmacogenomics J Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Avenet, NJ : Nature Pub. Group, c2001-
    • الموضوع:
      Genetic Variation*; Brain/*drug effects ; Nerve Tissue Proteins/*genetics ; Nerve Tissue Proteins/*metabolism ; Nicotinic Agonists/*adverse effects ; Smoking/*genetics ; Tobacco Use Disorder/*genetics; Adolescent ; Adult ; Aged ; Animals ; Autopsy ; Brain/metabolism ; Gene Frequency ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Linear Models ; Logistic Models ; Male ; Mecamylamine/pharmacology ; Mice ; Mice, 129 Strain ; Middle Aged ; Nicotinic Antagonists/pharmacology ; Phenotype ; RNA, Messenger/metabolism ; Time Factors ; Virginia ; Young Adult
    • نبذة مختصرة :
      The histidine triad nucleotide-binding protein-1 gene (HINT1) is implicated in schizophrenia and in the behavioral effects of morphine and amphetamine. Because nicotine dependence (ND) is highly comorbid with schizophrenia and other substance abuse, we examined the association of HINT1 with ND. Association analyses from two independent samples show that HINT1 gene variants are associated with ND phenotypes. Furthermore, human postmortem mRNA expression shows that smoking status and genotype influence HINT1 expression in the brain. In animal studies, western blot analyses show an increase of HINT1 protein level in the mouse nucleus accumbens (NAc) after chronic nicotine exposure. This increase was reduced after treatment with the nicotinic-receptor antagonist mecamylamine, and 24 and 72 h after cessation of nicotine treatment. These results indicate a genetic association between HINT1 variants and ND, and indicate that nicotine-induced modulation of HINT1 level may be involved in mechanisms of excess smoking.
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    • Grant Information:
      K01 DA019498 United States DA NIDA NIH HHS; R01 DA011287 United States DA NIDA NIH HHS; DA-011287 United States DA NIDA NIH HHS; DA-019498 United States DA NIDA NIH HHS
    • الرقم المعرف:
      0 (HINT1 protein, human)
      0 (Hint1 protein, mouse)
      0 (Nerve Tissue Proteins)
      0 (Nicotinic Agonists)
      0 (Nicotinic Antagonists)
      0 (RNA, Messenger)
      6EE945D3OK (Mecamylamine)
    • الموضوع:
      Date Created: 20100602 Date Completed: 20111115 Latest Revision: 20211020
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC4073884
    • الرقم المعرف:
      10.1038/tpj.2010.41
    • الرقم المعرف:
      20514075