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Genetic polymorphisms of the T-cell coreceptors CD28 and CTLA-4 in Afro- and Euro-Brazilians.

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  • المؤلفون: Pincerati MR;Pincerati MR; Dalla-Costa R; Pavoni DP; Petzl-Erler ML
  • المصدر:
    International journal of immunogenetics [Int J Immunogenet] 2010 Aug; Vol. 37 (4), pp. 253-61. Date of Electronic Publication: 2010 Apr 30.
  • نوع النشر :
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Blackwell Pub Country of Publication: England NLM ID: 101232337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-313X (Electronic) Linking ISSN: 17443121 NLM ISO Abbreviation: Int J Immunogenet Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Oxford, UK : Blackwell Pub., c2005-
    • الموضوع:
      Microsatellite Repeats* ; Polymorphism, Single Nucleotide*; Antigens, CD/*genetics ; Black People/*genetics ; CD28 Antigens/*genetics ; White People/*genetics; Africa/ethnology ; Alleles ; Brazil ; CTLA-4 Antigen ; Chromosomes, Human, Pair 2/genetics ; Europe/ethnology ; Gene Frequency ; Genotype ; Haplotypes/genetics ; Humans ; Linkage Disequilibrium
    • نبذة مختصرة :
      CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) are two receptors that have complementary functions in control of T-cell activation. Polymorphisms of their genes, CD28 and CTLA4, might confer differential susceptibility to diseases resulting from unbalanced or inefficient immune responses. Thus far, little is known about the CD28 polymorphism in populations and even for CTLA4 just one or two single nucleotide polymorphisms (SNPs) are usually analysed. To assess the allelic and haplotypic diversity and linkage disequilibrium in the Brazilian population, two samples differing according to predominant ancestry - African or European - have been analysed for seven SNPs, CD28 -372(G>A), and int3 17(T>C); CTLA4 -1722(T>C), -1577(G>A) -318(C>T), 49(A>G), 6230(G>A) also named CT60, and three microsatellites, CD28 (CAA)n, CTLA4 (AT)n and D2S72 (CA)n. The two population strata show little differentiation, the only significant differences being the allele frequencies of the CTLA4 -1577(G>A) SNP and the CTLA4 (AT)n microsatellite (P = 0.018 and P = 0.007, respectively). Linkage disequilibrium is high, especially between the CTLA4 polymorphisms. However, low r(2) values indicate that none of the markers is a tag SNP in these populations. These results provide valuable information for optimal selection of markers for use in future association studies. We conclude that disease association studies and functional studies addressing the possible consequences of polymorphisms of the 2q33 genomic region should consider haplotypic data besides analysis of individual polymorphisms.
    • الرقم المعرف:
      0 (Antigens, CD)
      0 (CD28 Antigens)
      0 (CTLA-4 Antigen)
      0 (CTLA4 protein, human)
    • الموضوع:
      Date Created: 20100519 Date Completed: 20101122 Latest Revision: 20221207
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.1111/j.1744-313X.2010.00917.x
    • الرقم المعرف:
      20477885