Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study.

Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE

Publication: 2001- : London : BioMed Central Ltd.
Original Publication: London : Current Science Ltd., c2000-

Exercise Tolerance* ; Quality of Life*; Anxiety/*epidemiology ; Anxiety/*physiopathology ; Emphysema/*epidemiology ; Emphysema/*physiopathology ; Pulmonary Disease, Chronic Obstructive/*epidemiology ; Pulmonary Disease, Chronic Obstructive/*physiopathology; Aged ; Comorbidity ; Cross-Sectional Studies ; Female ; Humans ; Incidence ; Male ; Risk Assessment ; Risk Factors ; United States

Background: Anxiety in patients with chronic obstructive pulmonary disease (COPD) is associated with self-reported disability. The purpose of this study is to determine whether there is an association between anxiety and functional measures, quality of life and dyspnea.
Methods: Data from 1828 patients with moderate to severe emphysema enrolled in the National Emphysema Treatment Trial (NETT), collected prior to rehabilitation and randomization, were used in linear regression models to test the association between anxiety symptoms, measured by the Spielberger State Trait Anxiety Inventory (STAI) and: (a) six-minute walk distance test (6 MWD), (b) cycle ergometry peak workload, (c) St. Georges Respiratory Questionnaire (SRGQ), and (d) UCSD Shortness of Breath Questionnaire (SOBQ), after controlling for potential confounders including age, gender, FEV1 (% predicted), DLCO (% predicted), and the Beck Depression Inventory (BDI).
Results: Anxiety was significantly associated with worse functional capacity [6 MWD (B = -0.944, p < .001), ergometry peak workload (B = -.087, p = .04)], quality of life (B = .172, p < .001) and shortness of breath (B = .180, p < .001). Regression coefficients show that a 10 point increase in anxiety score is associated with a mean decrease in 6 MWD of 9 meters, a 1 Watt decrease in peak exercise workload, and an increase of almost 2 points on both the SGRQ and SOBQ.
Conclusion: In clinically stable patients with moderate to severe emphysema, anxiety is associated with worse exercise performance, quality of life and shortness of breath, after accounting for the influence of demographic and physiologic factors known to affect these outcomes.
Trial Registration: ClinicalTrials.gov NCT00000606.

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ClinicalTrials.gov NCT00000606

Date Created: 20100311 Date Completed: 20100520 Latest Revision: 20220318

20221213

PMC2848143

10.1186/1465-9921-11-29

20214820