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iTRAQ-coupled 2D LC-MS/MS analysis of secreted proteome of HBV-replicating HepG2 cells: potential in biomarkers for prognosis of HCC.

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  • المؤلفون: Feng H;Feng H; Wang M; Chen WN
  • المصدر:
    Current microbiology [Curr Microbiol] 2010 Oct; Vol. 61 (4), pp. 280-4. Date of Electronic Publication: 2010 Feb 18.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Springer International Country of Publication: United States NLM ID: 7808448 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0991 (Electronic) Linking ISSN: 03438651 NLM ISO Abbreviation: Curr Microbiol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: New York, Springer International.
    • الموضوع:
      Proteome*; Biomarkers/*analysis ; Biomarkers, Tumor/*analysis ; Carcinoma, Hepatocellular/*diagnosis ; Hepatitis B virus/*genetics ; Hepatitis B virus/*physiology; Chromatography, Liquid ; Hep G2 Cells ; Hepatitis B ; Humans ; Liver Neoplasms/diagnosis ; Mass Spectrometry ; Prognosis ; Proteomics ; Tandem Mass Spectrometry ; Transfection ; Virus Replication
    • نبذة مختصرة :
      Hepatitis B virus (HBV) infection remains a major health concern with more than 350 million carriers in the world. It is associated with acute and chronic liver diseases including hepatocellular carcinoma (HCC). The early detection of severe liver diseases related to HBV is crucial for the effective treatment. This work aims to investigate the secreted proteins in our recently established cell-based HBV replication system, using isobaric tags for relative and absolute quantitation (iTRAQ)-coupled 2D LC-MS/MS proteomics approach. Such proteins are reflective of early events of HBV infection and thus may have potential as prognostic biomarkers for development of liver diseases.
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    • الرقم المعرف:
      0 (Biomarkers)
      0 (Biomarkers, Tumor)
      0 (Proteome)
    • الموضوع:
      Date Created: 20100219 Date Completed: 20110112 Latest Revision: 20211020
    • الموضوع:
      20221213
    • الرقم المعرف:
      10.1007/s00284-010-9608-3
    • الرقم المعرف:
      20165850