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Ozone exposure enhances mast-cell inflammation in asthmatic airways despite inhaled corticosteroid therapy.

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  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 8910739 Publication Model: Print Cited Medium: Internet ISSN: 1091-7691 (Electronic) Linking ISSN: 08958378 NLM ISO Abbreviation: Inhal Toxicol Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: New York, N.Y. : Hemisphere Pub. Corp., c1989-
    • الموضوع:
      Adrenal Cortex Hormones/*therapeutic use ; Asthma/*chemically induced ; Asthma/*pathology ; Inflammation/*pathology ; Mast Cells/*pathology ; Oxidants, Photochemical/*toxicity ; Ozone/*toxicity; Administration, Inhalation ; Adrenal Cortex Hormones/administration & dosage ; Adult ; Asthma/drug therapy ; Bronchoalveolar Lavage Fluid/cytology ; Cell Count ; Female ; Forced Expiratory Flow Rates ; Forced Expiratory Volume ; Humans ; Male ; Mast Cells/drug effects ; Middle Aged ; Peroxidase/metabolism ; Respiratory Function Tests ; Vital Capacity/drug effects ; Young Adult
    • نبذة مختصرة :
      Asthmatics are recognised to be more susceptible than healthy individuals to adverse health effects caused by exposure to the common air pollutant ozone. Ozone has been reported to induce airway neutrophilia in mild asthmatics, but little is known about how it affects the airways of asthmatic subjects on inhaled corticosteroids. We hypothesised that ozone exposure would exacerbate the pre-existent asthmatic airway inflammation despite regular inhaled corticosteroid treatment. Therefore, we exposed subjects with persistent asthma on inhaled corticosteroid therapy to 0.2 ppm ozone or filtered air for 2 h, on 2 separate occasions. Lung function was evaluated before and immediately after exposure, while bronchoscopy was performed 18 h post exposure. Compared to filtered air, ozone exposure increased airway resistance. Ozone significantly enhanced neutrophil numbers and myeloperoxidase levels in airway lavages, and induced a fourfold increase in bronchial mucosal mast cell numbers. The present findings indicate that ozone worsened asthmatic airway inflammation and offer a possible biological explanation for the epidemiological findings of increased need for rescue medication and hospitalisation in asthmatic people following exposure to ambient ozone.
    • الرقم المعرف:
      0 (Adrenal Cortex Hormones)
      0 (Oxidants, Photochemical)
      66H7ZZK23N (Ozone)
      EC 1.11.1.7 (Peroxidase)
    • الموضوع:
      Date Created: 20100105 Date Completed: 20100325 Latest Revision: 20131121
    • الموضوع:
      20221213
    • الرقم المعرف:
      10.3109/08958370903005736
    • الرقم المعرف:
      20044881