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Solid-State Nuclear Magnetic Resonance Spectroscopy for Analyzing Polymorphic Drug Forms and Formulations.

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  • المؤلفون: Offerdahl, Thomas J.
  • المصدر:
    Pharmaceutical Technology. Feb2006, Vol. 30 Issue 2, NONDESTRUCTIVE ANALYTICAL METHODS ps24-s42. 17p. 2 Charts, 15 Graphs.
  • معلومة اضافية
    • الموضوع:
      NUCLEAR magnetic resonance spectroscopy; NUCLEAR spectroscopy; EXCIPIENTS; DRUG development; X-ray diffraction
    • نبذة مختصرة :
      The article discusses the advantages and disadvantages of using solid-state nuclear magnetic resonance (SSNMR) spectroscopy in analyzing polymorphic drug forms and formulations. The SSNMR methods include differential scanning calorimetry, single crystal X-ray diffraction, X-ray powder diffraction, infrared spectroscopy, and Raman spectroscopy. SSNMR spectroscopy could be used bulk drugs formulations in distinguishing the excipient peaks of the NMR spectrum.