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Baseline Ad5 serostatus does not predict Ad5 HIV vaccine-induced expansion of adenovirus-specific CD4+ T cells.

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  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
    • بيانات النشر:
      Publication: New York Ny : Nature Publishing Company
      Original Publication: New York, NY : Nature Pub. Co., [1995-
    • الموضوع:
      AIDS Vaccines/*immunology ; Acquired Immunodeficiency Syndrome/*therapy ; Adenoviridae/*immunology ; Antibodies, Viral/*blood ; CD4-Positive T-Lymphocytes/*immunology ; T-Cell Antigen Receptor Specificity/*immunology; Acquired Immunodeficiency Syndrome/blood ; Acquired Immunodeficiency Syndrome/diagnosis ; Acquired Immunodeficiency Syndrome/immunology ; CD4 Lymphocyte Count ; Cell Proliferation ; HIV-1/immunology ; Humans ; Prognosis ; Vaccines, Synthetic/immunology
    • نبذة مختصرة :
      The mechanisms underlying possible increased HIV-1 acquisition in adenovirus 5 (Ad5)-seropositive subjects vaccinated with Ad5-HIV-1 vectors in the Merck STEP trial remain unclear. We find that Ad5 serostatus does not predict Ad5-specific CD4(+) T cell frequency, and we did not observe durable significant differences in Ad5-specific CD4(+) T cells between Ad5-seropositive and Ad5-seronegative subjects after vaccination. These findings indicate no causative role for Ad5-specific CD4(+) T cells in increasing HIV-1 susceptibility in the STEP trial.
    • Comments:
      Erratum in: Nat Med. 2009 Nov;15(11):1333. Makedonas, George [added].
    • References:
      Nature. 1994 Oct 27;371(6500):802-6. (PMID: 7523956)
      Clin Infect Dis. 2008 Jun 1;46(11):1769-81. (PMID: 18433307)
      Virology. 1996 May 1;219(1):220-7. (PMID: 8623532)
      Hum Gene Ther. 2004 Mar;15(3):293-304. (PMID: 15018738)
      J Exp Med. 2008 Jan 21;205(1):7-12. (PMID: 18195078)
      J Gen Virol. 1991 Feb;72 ( Pt 2):359-67. (PMID: 1993876)
      J Gen Virol. 1977 Jul;36(1):59-74. (PMID: 886304)
      Lancet. 2008 Nov 29;372(9653):1881-1893. (PMID: 19012954)
    • Grant Information:
      U19 AI074078 United States AI NIAID NIH HHS; U19 AI074078-010003 United States AI NIAID NIH HHS; U19 AI074078-020003 United States AI NIAID NIH HHS; U19AI074078 United States AI NIAID NIH HHS
    • الرقم المعرف:
      0 (AIDS Vaccines)
      0 (Antibodies, Viral)
      0 (Vaccines, Synthetic)
    • الموضوع:
      Date Created: 20090722 Date Completed: 20090825 Latest Revision: 20220408
    • الموضوع:
      20221213
    • الرقم المعرف:
      PMC2723179
    • الرقم المعرف:
      10.1038/nm.1989
    • الرقم المعرف:
      19620962