Collective cell migration in morphogenesis, regeneration and cancer.

Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962782 Publication Model: Print Cited Medium: Internet ISSN: 1471-0080 (Electronic) Linking ISSN: 14710072 NLM ISO Abbreviation: Nat Rev Mol Cell Biol Subsets: MEDLINE

Original Publication: London, UK : Nature Pub. Group, [2000-

Cell Movement* ; Morphogenesis* ; Regeneration*; Neoplasms/*pathology; Animals ; Humans ; Models, Biological

The collective migration of cells as a cohesive group is a hallmark of the tissue remodelling events that underlie embryonic morphogenesis, wound repair and cancer invasion. In such migration, cells move as sheets, strands, clusters or ducts rather than individually, and use similar actin- and myosin-mediated protrusions and guidance by extrinsic chemotactic and mechanical cues as used by single migratory cells. However, cadherin-based junctions between cells additionally maintain 'supracellular' properties, such as collective polarization, force generation, decision making and, eventually, complex tissue organization. Comparing different types of collective migration at the molecular and cellular level reveals a common mechanistic theme between developmental and cancer research.

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Date Created: 20090624 Date Completed: 20090707 Latest Revision: 20240305

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