The ANKK1 kinase gene and psychiatric disorders.

Publisher: Springer Country of Publication: United States NLM ID: 100929017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-3524 (Electronic) Linking ISSN: 10298428 NLM ISO Abbreviation: Neurotox Res Subsets: MEDLINE

Publication: <2009-> : New York : Springer
Original Publication: [Amsterdam?] : Harwood Academic Publishers,

Genetic Predisposition to Disease*; Mental Disorders/*genetics ; Protein Serine-Threonine Kinases/*genetics; Animals ; Chromosome Mapping ; Humans ; Mental Disorders/classification ; Phylogeny ; Polymorphism, Single Nucleotide/genetics ; Psychiatric Status Rating Scales ; Receptors, Dopamine D2/genetics

The TaqIA single nucleotide polymorphism (SNP, rs1800497), which is located in the gene that codes for the putative kinase ANKK1 (ANKK1) near the termination codon of the D2 dopamine receptor gene (DRD2; chromosome 11q22-q23), is the most studied genetic variation in a broad range of psychiatric disorders and personality traits. A large number of individual genetic association studies have found that the TaqIA SNP is linked to alcoholism and antisocial traits. In addition, it has also been related to other conditions such as schizophrenia, eating disorders, and some behavioral childhood disorders. The TaqIA A1 allele is mainly associated with addictions, antisocial disorders, eating disorders, and attention-deficit/hyperactivity disorders, while the A2 allele occurs more frequently in schizophrenic and obsessive-compulsive patients. Current data show that the TaqIA polymorphism may be a marker of both DRD2 and ANKK1 genetic variants. ANKK1 would belong to a family of kinases involved in signal transduction. This raises the question of whether signaling players intervene in the pathophysiology of psychiatric disorders. Basic research on the ANKK1 protein and its putative interaction with the D2 dopamine receptor could shed light on this issue.

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0 (Receptors, Dopamine D2)
EC 2.7.11.1 (ANKK1 protein, human)
EC 2.7.11.1 (Protein Serine-Threonine Kinases)

Date Created: 20090616 Date Completed: 20100122 Latest Revision: 20211203

20231215

10.1007/s12640-009-9046-9

19526298