Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
    • بيانات النشر:
      Publication: : Washington, DC : American Association for the Advancement of Science
      Original Publication: New York, N.Y. : [s.n.] 1880-
    • الموضوع:
      Bacterial Adhesion*; Blood-Brain Barrier/*microbiology ; Brain/*blood supply ; Endothelium, Vascular/*microbiology ; Fimbriae, Bacterial/*physiology ; Intercellular Junctions/*metabolism ; Neisseria meningitidis/*physiology; Adaptor Proteins, Signal Transducing/metabolism ; Antigens, CD/metabolism ; Blood-Brain Barrier/metabolism ; Brain/cytology ; Brain/microbiology ; Cadherins/metabolism ; Catenins ; Cell Adhesion Molecules/metabolism ; Cell Cycle Proteins/metabolism ; Cell Line ; Cell Polarity ; Endothelial Cells/metabolism ; Endothelial Cells/microbiology ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/ultrastructure ; Humans ; Intercellular Junctions/microbiology ; Intercellular Junctions/ultrastructure ; Membrane Proteins/metabolism ; Neisseria meningitidis/pathogenicity ; Phosphoproteins/metabolism ; Protein Kinase C/metabolism ; cdc42 GTP-Binding Protein/metabolism ; Delta Catenin
    • نبذة مختصرة :
      Type IV pili mediate the initial interaction of many bacterial pathogens with their host cells. In Neisseria meningitidis, the causative agent of cerebrospinal meningitis, type IV pili-mediated adhesion to brain endothelial cells is required for bacteria to cross the blood-brain barrier. Here, type IV pili-mediated adhesion of N. meningitidis to human brain endothelial cells was found to recruit the Par3/Par6/PKCzeta polarity complex that plays a pivotal role in the establishment of eukaryotic cell polarity and the formation of intercellular junctions. This recruitment leads to the formation of ectopic intercellular junctional domains at the site of bacteria-host cell interaction and a subsequent depletion of junctional proteins at the cell-cell interface with opening of the intercellular junctions of the brain-endothelial interface.
    • Comments:
      Comment in: Dev Cell. 2011 Jan 18;20(1):7-8. doi: 10.1016/j.devcel.2010.12.011. (PMID: 21238920)
    • References:
      Cell. 2000 Jan 21;100(2):209-19. (PMID: 10660044)
      Nat Cell Biol. 2000 Aug;2(8):531-9. (PMID: 10934474)
      J Cell Sci. 2008 Apr 1;121(Pt 7):989-1001. (PMID: 18319301)
      Mol Microbiol. 1993 May;8(4):719-25. (PMID: 8332064)
      Planta Med. 2007 Apr;73(4):330-5. (PMID: 17372866)
      J Cell Biol. 2005 Sep 12;170(6):895-901. (PMID: 16157700)
      Nature. 1995 Jan 26;373(6512):357-9. (PMID: 7830772)
      Nature. 2000 Sep 7;407(6800):98-102. (PMID: 10993081)
      J Cell Biol. 2001 Oct 1;155(1):133-43. (PMID: 11581290)
      PLoS Pathog. 2009 Feb;5(2):e1000314. (PMID: 19247442)
      Mol Microbiol. 1991 Aug;5(8):1831-41. (PMID: 1722554)
      Genes Cells. 2001 Aug;6(8):721-31. (PMID: 11532031)
      Clin Microbiol Rev. 2000 Jan;13(1):144-66, table of contents. (PMID: 10627495)
      Mol Microbiol. 1999 Jun;32(6):1316-32. (PMID: 10383771)
      Nat Cell Biol. 2003 Feb;5(2):137-42. (PMID: 12545177)
      FASEB J. 2005 Nov;19(13):1872-4. (PMID: 16141364)
      Infect Immun. 2005 May;73(5):3072-82. (PMID: 15845515)
      J Cell Biol. 1996 Jul;134(1):149-63. (PMID: 8698811)
      Mol Microbiol. 1997 Aug;25(4):639-47. (PMID: 9379894)
      J Cell Sci. 2002 Mar 15;115(Pt 6):1231-41. (PMID: 11884522)
      J Infect Dis. 1997 Nov;176(5):1285-92. (PMID: 9359730)
      Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10882-7. (PMID: 17576929)
      Annu Rev Microbiol. 2002;56:289-314. (PMID: 12142488)
      J Cell Sci. 2006 Mar 15;119(Pt 6):979-87. (PMID: 16525119)
      J Exp Med. 2006 Aug 7;203(8):1939-50. (PMID: 16864659)
      J Cell Sci. 2007 Jul 15;120(Pt 14):2352-65. (PMID: 17606991)
    • Contributed Indexing:
      Indexing Agency: NLM Local ID #: HALMS767121.
    • الرقم المعرف:
      0 (Adaptor Proteins, Signal Transducing)
      0 (Antigens, CD)
      0 (Cadherins)
      0 (Catenins)
      0 (Cell Adhesion Molecules)
      0 (Cell Cycle Proteins)
      0 (Membrane Proteins)
      0 (PARD3 protein, human)
      0 (PARD6A protein, human)
      0 (Phosphoproteins)
      0 (cadherin 5)
      EC 2.7.11.1 (protein kinase C zeta)
      EC 2.7.11.13 (Protein Kinase C)
      EC 3.6.5.2 (cdc42 GTP-Binding Protein)
      0 (Delta Catenin)
    • الموضوع:
      Date Created: 20090613 Date Completed: 20090715 Latest Revision: 20230207
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC3980637
    • الرقم المعرف:
      10.1126/science.1173196
    • الرقم المعرف:
      19520910