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Helicobacter pylori cag pathogenicity island-positive strains induce syndecan-4 expression in gastric epithelial cells.

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  • معلومة اضافية
    • المصدر:
      Publisher: Blackwell Pub Country of Publication: England NLM ID: 9315554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1574-695X (Electronic) Linking ISSN: 09288244 NLM ISO Abbreviation: FEMS Immunol Med Microbiol Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2006- : Oxford : Blackwell Pub.
      Original Publication: Amsterdam ; New York : Published by Elsevier Science Publishers on behalf of the Federation of European Microbiological Societies, [1993-
    • الموضوع:
      Bacterial Adhesion* ; Genomic Islands*; Epithelial Cells/*microbiology ; Helicobacter pylori/*pathogenicity ; Syndecan-4/*biosynthesis; Antigens, Bacterial/genetics ; Bacterial Proteins/genetics ; Gastric Mucosa/pathology ; Gene Expression Profiling ; Helicobacter pylori/genetics ; Humans
    • نبذة مختصرة :
      Helicobacter pylori is recognized as the main cause of gastritis and is associated with gastric carcinogenesis. Syndecan-4 represents the major source of heparan sulfate (HS) in the gastric cells. HS proteoglycans expressed on the cell surface constitute targets for H. pylori at the early stage of infection. The aim of this study was to determine whether H. pylori induction of syndecan-4 expression is affected by the virulence characteristics of the infecting strain, namely the cytotoxic-associated gene (cag) pathogenicity island (PAI). We observed that individuals infected with highly pathogenic H. pylori strains express syndecan-4 in the foveolar epithelium of the gastric mucosa. The association between the cagPAI status of the infecting strain and syndecan-4 expression was further demonstrated by infection of gastric epithelial cell lines with a panel of cagPAI(+) and cagPAI(-)H. pylori strains, showing that expression of syndecan-4 was significantly increased in response to infection with the highly pathogenic strains. Moreover, infection of gastric cells with cagA and cagE mutant strains further confirmed that syndecan-4 induction is dependent on an intact cagPAI. The present study shows that highly pathogenic H. pylori strains induce syndecan-4 expression, both in human gastric mucosa and in gastric cell lines, in a cagPAI-dependent manner.
    • الرقم المعرف:
      0 (Antigens, Bacterial)
      0 (Bacterial Proteins)
      0 (SDC4 protein, human)
      0 (Syndecan-4)
      0 (cagA protein, Helicobacter pylori)
    • الموضوع:
      Date Created: 20090613 Date Completed: 20090908 Latest Revision: 20090715
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.1111/j.1574-695X.2009.00569.x
    • الرقم المعرف:
      19519784