The emerging role of nuclear architecture in DNA repair and genome maintenance.

Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0080 (Electronic) Linking ISSN: 14710072 NLM ISO Abbreviation: Nat Rev Mol Cell Biol Subsets: MEDLINE

Original Publication: London, UK : Nature Pub. Group, [2000-

DNA Repair* ; Genome*; Cell Nucleus/*genetics; Animals ; Chromatin/metabolism ; DNA Damage ; Humans ; Models, Biological

DNA repair and maintenance of genome stability are crucial to cellular and organismal function, and defects in these processes have been implicated in cancer and ageing. Detailed molecular, biochemical and genetic analyses have outlined the molecular framework involved in cellular DNA-repair pathways, but recent cell-biological approaches have revealed important roles for the spatial and temporal organization of the DNA-repair machinery during the recognition of DNA lesions and the assembly of repair complexes. It has also become clear that local higher-order chromatin structure, chromatin dynamics and non-random global genome organization are key factors in genome maintenance. These cell-biological features of DNA repair illustrate an emerging role for nuclear architecture in multiple aspects of genome maintenance.

124

Annu Rev Genet. 2006;40:363-83. (PMID: 16895466)
Semin Cancer Biol. 2007 Feb;17(1):80-90. (PMID: 17137790)
Genes Dev. 2005 Jul 15;19(14):1656-61. (PMID: 16024655)
Mol Cell Biol. 2006 May;26(9):3649-58. (PMID: 16612003)
EMBO J. 2008 Feb 20;27(4):581-8. (PMID: 18285819)
Genes Dev. 2006 Sep 1;20(17):2437-49. (PMID: 16951256)
Mol Cell Biol. 2005 Jun;25(12):4903-13. (PMID: 15923609)
Science. 2004 Dec 17;306(5704):2084-7. (PMID: 15528408)
Nature. 2005 Jul 14;436(7048):294-8. (PMID: 16015338)
PLoS Biol. 2004 May;2(5):E110. (PMID: 15138496)
Curr Opin Genet Dev. 2007 Apr;17(2):126-31. (PMID: 17320375)
Nature. 1999 Dec 2;402(6761):555-60. (PMID: 10591219)
Cell. 2003 Aug 8;114(3):371-383. (PMID: 12914701)
Nat Cell Biol. 2002 Dec;4(12):993-7. (PMID: 12447390)
Nature. 2000 Dec 21-28;408(6815):1001-4. (PMID: 11140636)
Mol Cell Biol. 2009 Jan;29(2):526-37. (PMID: 18981219)
Science. 2007 May 25;316(5828):1194-8. (PMID: 17525340)
Mol Cell. 2008 Jul 25;31(2):167-77. (PMID: 18657500)
Nature. 2006 Jan 26;439(7075):497-501. (PMID: 16299494)
Nat Genet. 2004 Apr;36(4):331-4. (PMID: 15054488)
Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13513-8. (PMID: 15353583)
Cell. 2004 Dec 17;119(6):767-75. (PMID: 15607974)
PLoS Biol. 2004 May;2(5):E131. (PMID: 15045029)
Cell. 2008 Nov 28;135(5):907-18. (PMID: 19041753)
Mol Cell Biol. 2005 Jun;25(12):5292-305. (PMID: 15923642)
Genome Biol. 2004;5(7):R44. (PMID: 15239829)
J Exp Med. 2003 Jun 16;197(12):1767-78. (PMID: 12810694)
J Exp Med. 2004 Jun 21;199(12):1671-7. (PMID: 15197225)
Nature. 2007 Jan 25;445(7126):379-781. (PMID: 17251970)
J Biol Chem. 2008 Jul 11;283(28):19478-88. (PMID: 18480059)
Mol Cell Biol. 2005 Oct;25(19):8430-43. (PMID: 16166626)
Nat Cell Biol. 2007 Jun;9(6):683-90. (PMID: 17486112)
EMBO Rep. 2008 Aug;9(8):795-801. (PMID: 18583988)
Mol Cell. 2004 Dec 22;16(6):979-90. (PMID: 15610740)
Genes Dev. 2008 Feb 1;22(3):297-302. (PMID: 18245444)
Cell Cycle. 2005 Jun;4(6):737-40. (PMID: 15908798)
Science. 2007 May 25;316(5828):1198-202. (PMID: 17525341)
Science. 2008 Oct 24;322(5901):597-602. (PMID: 18948542)
Cell. 2006 Dec 29;127(7):1361-73. (PMID: 17190600)
Cell. 2007 Nov 30;131(5):901-14. (PMID: 18001825)
Science. 2004 Jan 16;303(5656):343-8. (PMID: 14645854)
J Cell Biol. 2006 Mar 13;172(6):823-34. (PMID: 16520385)
EMBO J. 2002 Apr 15;21(8):2030-7. (PMID: 11953322)
Nature. 2003 Jan 30;421(6922):499-506. (PMID: 12556884)
Blood. 2000 Sep 1;96(5):1940-6. (PMID: 10961898)
Nat Cell Biol. 2003 Jul;5(7):675-9. (PMID: 12792649)
Science. 1998 Apr 24;280(5363):590-2. (PMID: 9554850)
Blood. 1999 Feb 15;93(4):1197-207. (PMID: 9949162)
Cell Cycle. 2008 Dec;7(23):3653-8. (PMID: 19029795)
J Cell Biol. 2007 Jul 16;178(2):209-18. (PMID: 17635934)
J Cell Biol. 2007 Dec 31;179(7):1337-45. (PMID: 18166648)
Cell Cycle. 2003 Sep-Oct;2(5):479-83. (PMID: 12963848)
Mol Cell. 2005 Dec 9;20(5):801-9. (PMID: 16310392)
Curr Biol. 2006 Aug 8;16(15):1559-64. (PMID: 16890532)
DNA Repair (Amst). 2004 Aug-Sep;3(8-9):997-1007. (PMID: 15279786)
Chromosoma. 2005 Aug;114(3):146-54. (PMID: 15988581)
Cell Cycle. 2005 Jun;4(6):780-3. (PMID: 15970663)
Science. 2002 May 3;296(5569):922-7. (PMID: 11934988)
Cell. 2006 Nov 3;127(3):481-93. (PMID: 17081972)
Cell. 2003 Aug 8;114(3):359-70. (PMID: 12914700)
Eukaryot Cell. 2008 May;7(5):800-13. (PMID: 18344406)
Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1644-9. (PMID: 14711989)
Nat Cell Biol. 2007 Jun;9(6):675-82. (PMID: 17486118)
Cell. 2005 Dec 29;123(7):1213-26. (PMID: 16377563)
Nat Cell Biol. 2006 Aug;8(8):870-6. (PMID: 16862143)
Nature. 2005 Nov 17;438(7066):379-83. (PMID: 16292314)
Nature. 2007 Jun 21;447(7147):951-8. (PMID: 17581578)
Science. 2005 Apr 22;308(5721):551-4. (PMID: 15790808)
EMBO J. 2006 Sep 6;25(17):3986-97. (PMID: 16932743)
Science. 2007 Dec 7;318(5856):1637-40. (PMID: 18006705)
Curr Opin Genet Dev. 2007 Oct;17(5):435-42. (PMID: 17905579)
Nature. 2000 Nov 23;408(6811):433-9. (PMID: 11100718)
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11200-5. (PMID: 18678890)
J Cell Biol. 2008 Apr 21;181(2):227-40. (PMID: 18411308)
Nat Rev Cancer. 2007 Nov;7(11):861-9. (PMID: 17943134)
Mol Cell. 2004 Dec 22;16(6):1017-25. (PMID: 15610743)
Trends Cell Biol. 2003 Sep;13(9):458-62. (PMID: 12946624)
Nature. 2008 May 29;453(7195):682-6. (PMID: 18438399)
Cell Stem Cell. 2008 May 8;2(5):437-47. (PMID: 18462694)
Cell. 2004 Dec 17;119(6):777-88. (PMID: 15607975)
J Cell Biol. 2008 Apr 21;181(2):213-26. (PMID: 18411307)
Mol Cell. 2008 Jul 11;31(1):33-46. (PMID: 18614045)
Curr Opin Cell Biol. 2002 Apr;14(2):237-45. (PMID: 11891124)
Cell. 2007 Nov 30;131(5):887-900. (PMID: 18001824)
Mol Cell. 2008 Apr 11;30(1):86-97. (PMID: 18406329)
Science. 2007 May 25;316(5828):1202-5. (PMID: 17525342)
J Cell Biol. 2007 Sep 24;178(7):1101-8. (PMID: 17893239)
Cell. 2008 Jul 25;134(2):231-43. (PMID: 18662539)
J Cell Biol. 2006 Apr 24;173(2):195-206. (PMID: 16618811)
Mol Cell. 2008 May 23;30(4):486-97. (PMID: 18498750)
Cell. 2004 Sep 17;118(6):699-713. (PMID: 15369670)
Nature. 2004 Nov 18;432(7015):406-11. (PMID: 15525939)
PLoS Genet. 2008 Aug 15;4(8):e1000155. (PMID: 18704159)
Nat Rev Genet. 2007 Feb;8(2):104-15. (PMID: 17230197)
Curr Opin Cell Biol. 2004 Jun;16(3):328-34. (PMID: 15145359)
Science. 2007 Feb 2;315(5812):649-52. (PMID: 17272722)
Nat Cell Biol. 2006 Jan;8(1):91-9. (PMID: 16341205)
Curr Biol. 2002 Oct 1;12(19):1692-7. (PMID: 12361574)
Nature. 2008 Nov 27;456(7221):529-33. (PMID: 18931658)
Mol Cell Biol. 2007 Oct;27(20):7028-40. (PMID: 17709392)
Nature. 2008 Nov 27;456(7221):524-8. (PMID: 18931659)
Nat Cell Biol. 2003 Jun;5(6):572-7. (PMID: 12766777)
Cell. 2004 Nov 24;119(5):603-14. (PMID: 15550243)
Mol Cell Biol. 2008 Apr;28(8):2690-700. (PMID: 18285460)
Science. 2004 Jan 2;303(5654):92-5. (PMID: 14704429)
Chromosoma. 2007 Apr;116(2):79-93. (PMID: 17180700)
Mol Cell. 2004 Dec 22;16(6):991-1002. (PMID: 15610741)
Mol Cell. 2005 Sep 2;19(5):679-90. (PMID: 16137623)
Science. 2008 Jun 13;320(5882):1507-10. (PMID: 18483401)
Mol Cell. 2008 May 9;30(3):267-76. (PMID: 18471973)
Nature. 2002 Sep 26;419(6905):411-5. (PMID: 12353039)
PLoS Biol. 2006 May;4(5):e138. (PMID: 16623600)
Nat Genet. 2003 Jul;34(3):287-91. (PMID: 12808455)
Mol Cell Biol. 2002 Dec;22(23):8353-65. (PMID: 12417736)
Nat Cell Biol. 2009 Jan;11(1):92-6. (PMID: 19079244)
Genes Dev. 1995 Jul 15;9(14):1716-27. (PMID: 7622036)
Cell. 2007 Feb 23;128(4):787-800. (PMID: 17320514)
EMBO Rep. 2002 Apr;3(4):329-34. (PMID: 11897662)
Genes Dev. 2006 Jun 15;20(12):1583-96. (PMID: 16778077)
J Cell Biol. 1999 Sep 6;146(5):905-16. (PMID: 10477747)
J Biol Chem. 1998 Mar 6;273(10):5858-68. (PMID: 9488723)
Oncogene. 2007 Aug 13;26(37):5358-72. (PMID: 17694078)
EMBO J. 2004 Jul 7;23(13):2674-83. (PMID: 15201865)
EMBO J. 2007 Sep 19;26(18):4113-25. (PMID: 17762868)

Z01 BC010309 United States ImNIH Intramural NIH HHS; Z01 BC010309-09 United States ImNIH Intramural NIH HHS

0 (Chromatin)

Date Created: 20090312 Date Completed: 20090327 Latest Revision: 20240610

20250114

PMC3478884

10.1038/nrm2651

19277046