Modeling the genetic and environmental association between peer group deviance and cannabis use in male twins.

Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9304118 Publication Model: Print Cited Medium: Internet ISSN: 1360-0443 (Electronic) Linking ISSN: 09652140 NLM ISO Abbreviation: Addiction Subsets: MEDLINE

Publication: Oxford : Wiley-Blackwell
Original Publication: Abingdon, Oxfordshire, UK : Carfax Pub. Co., c1993-

Models, Genetic* ; Peer Group* ; Social Environment*; Diseases in Twins/*genetics ; Marijuana Abuse/*etiology; Adolescent ; Adult ; Age Factors ; Child ; Humans ; Male ; Marijuana Abuse/genetics ; Marijuana Abuse/psychology ; Phenotype ; Risk Factors ; Virginia/epidemiology

Background: Peer group deviance (PGD) is linked strongly to liability to drug use, including cannabis. Our aim was to model the genetic and environmental association, including direction of causation, between PGD and cannabis use (CU).
Method: Results were based on 1736 to 1765 adult males from the Mid-Atlantic Twin Registry with complete CU and PGD data measured retrospectively at three time-intervals between 15 and 25 years using a life-history calendar.
Results: At all ages, multivariate modeling showed that familial aggregation in PGD was explained by a combination of additive genetic and shared environmental effects. Moreover, the significant PGD-CU association was best explained by a CU-->PGD causal model in which large portions of the additive genetic (50-78%) and shared environmental variance (25-73%) in PGD were explained by CU.
Conclusions: Until recently PGD was assumed to be an environmental, upstream risk factor for CU. Our data are not consistent with this hypothesis. Rather, they suggest that the liability to affiliate with deviant peers is explained more clearly by a combination of genetic and environmental factors that are indexed by CU which sits as a 'risk indicator' in the causal pathway between genetic and environmental risks and the expression of PGD. This is consistent with a process of social selection by which the genetic and environmental risks in CU largely drive the propensity to affiliate with deviant peers.

Comment in: Addiction. 2009 Mar;104(3):439-40. doi: 10.1111/j.1360-0443.2008.02512.x. (PMID: 19207352)

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Date Created: 20090212 Date Completed: 20090515 Latest Revision: 20220310

20250114

PMC2844883

10.1111/j.1360-0443.2008.02457.x

19207350