Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees.

Publisher: Springer Country of Publication: Austria NLM ID: 9815663 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-1102 (Electronic) Linking ISSN: 14341816 NLM ISO Abbreviation: Arch Womens Ment Health Subsets: MEDLINE

Original Publication: Wien ; New York : Springer, c1998-

Personality*; Mood Disorders/*genetics ; Mood Disorders/*physiopathology ; Premenstrual Syndrome/*genetics; Adult ; Bipolar Disorder ; Depressive Disorder, Major/genetics ; Depressive Disorder, Major/psychology ; Female ; Humans ; Interviews as Topic ; Odds Ratio ; Pedigree ; Premenstrual Syndrome/psychology ; United States

We sought to determine whether premenstrual mood symptoms exhibit familial aggregation in bipolar disorder or major depression pedigrees. Two thousand eight hundred seventy-six women were interviewed with the Diagnostic Interview for Genetic Studies as part of either the NIMH Genetics Initiative Bipolar Disorder Collaborative study or the Genetics of Early Onset Major Depression (GenRED) study and asked whether they had experienced severe mood symptoms premenstrually. In families with two or more female siblings with bipolar disorder (BP) or major depressive disorder (MDD), we examined the odds of having premenstrual mood symptoms given one or more siblings with these symptoms. For the GenRED MDD sample we also assessed the impact of personality as measured by the NEO-FFI. Premenstrual mood symptoms did not exhibit familial aggregation in families with BP or MDD. We unexpectedly found an association between high NEO openness scores and premenstrual mood symptoms, but neither this factor, nor NEO neuroticism influenced evidence for familial aggregation of symptoms. Limitations include the retrospective interview, the lack of data on premenstrual dysphoric disorder, and the inability to control for factors such as medication use.

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Investigator: J Nurnberger; MJ Miller; ES Bowman; NL Rau; PR Moe; N Samavedy; R El-Mallakh; H Manji; DA Glitz; ET Meyer; C Smiley; T Foroud; L Flury; DM Dick; H Edenberg; J Rice; T Reich; A Goate; L Bierut; M McInnis; JR DePaulo; DF MacKinnon; FM Mondimore; JB Potash; PP Zandi; D Avramopoulos; J Payne; W Berrettini; W Byerley; M Vawter; W Coryell; R Crowe; E Gershon; J Badner; F McMahon; C Liu; A Sanders; M Caserta; S Dinwiddie; T Nguyen; D Harakal; J Kelsoe; R McKinney; W Scheftner; HM Kravitz; D Marta; A Vaughn-Brown; L Bederow; FJ McMahon; L Kassem; S Detera-Wadleigh; L Austin; DL Murphy

Date Created: 20090113 Date Completed: 20090514 Latest Revision: 20211028

20240513

PMC3845804

10.1007/s00737-008-0043-4

19137238