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Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging study.
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- معلومة اضافية
- المصدر:
Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
- بيانات النشر:
Publication: 2000- : Houndmills, Basingstoke, UK : Nature Publishing Group Specialist Journals
Original Publication: Houndmills, Hampshire, UK ; New York, NY : Stockton Press, c1996-
- الموضوع:
- نبذة مختصرة :
Schizophrenia is associated with structural brain abnormalities, but the timing of onset and course of these changes remains unclear. Longitudinal magnetic resonance imaging (MRI) studies have demonstrated progressive brain volume decreases in patients around and after the onset of illness, although considerable discrepancies exist regarding which brain regions are affected. The anatomical pattern of these progressive changes in schizophrenia is largely unknown. In this study, MRI scans were acquired repeatedly from 16 schizophrenia patients approximately 2 years apart following their first episode of illness, and also from 14 age-matched healthy subjects. Cortical Pattern Matching, in combination with Structural Image Evaluation, using Normalisation, of Atrophy, was applied to compare the rates of cortical surface contraction between patients and controls. Surface contraction in the dorsal surfaces of the frontal lobe was significantly greater in patients with first-episode schizophrenia (FESZ) compared with healthy controls. Overall, brain surface contraction in patients and healthy controls showed similar anatomical patterns, with that of the former group exaggerated in magnitude across the entire brain surface. That the pattern of structural change in the early course of schizophrenia corresponds so closely to that associated with normal development is consistent with the hypothesis that a schizophrenia-related factor interacts with normal adolescent brain developmental processes in the pathophysiology of schizophrenia. The exaggerated progressive changes seen in patients with schizophrenia may reflect an increased rate of synaptic pruning, resulting in excessive loss of neuronal connectivity, as predicted by the late neurodevelopmental hypothesis of the illness.
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- Grant Information:
R21 EB001561 United States EB NIBIB NIH HHS; AG016570 United States AG NIA NIH HHS; R01 LM005639-10 United States LM NLM NIH HHS; R21 EB001561-03 United States EB NIBIB NIH HHS; EB01651 United States EB NIBIB NIH HHS; MH65078 United States MH NIMH NIH HHS; U54 RR021813-01 United States RR NCRR NIH HHS; U54 RR021813 United States RR NCRR NIH HHS; RR021813 United States RR NCRR NIH HHS; LM05639 United States LM NLM NIH HHS; P50 AG016570-10 United States AG NIA NIH HHS; R01 MH065079 United States MH NIMH NIH HHS; R21 RR019771 United States RR NCRR NIH HHS; R01 LM005639 United States LM NLM NIH HHS; RR019771 United States RR NCRR NIH HHS; P50 AG016570 United States AG NIA NIH HHS; R21 RR019771-02 United States RR NCRR NIH HHS; P50 AG016570-090004 United States AG NIA NIH HHS; P50 AG016570-100004 United States AG NIA NIH HHS; R01 MH065079-05 United States MH NIMH NIH HHS
- الموضوع:
Date Created: 20080709 Date Completed: 20091211 Latest Revision: 20220311
- الموضوع:
20231215
- الرقم المعرف:
PMC2773126
- الرقم المعرف:
10.1038/mp.2008.34
- الرقم المعرف:
18607377
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