The effects of inflammatory response associated with traumatic spinal cord injury in cutaneous wound healing and on expression of transforming growth factor-beta1 (TGF-beta1) and platelet-derived growth factor (PDGF)-A at the wound site in rats.

Publisher: Informa Healthcare Country of Publication: England NLM ID: 9000468 Publication Model: Print Cited Medium: Print ISSN: 0897-7194 (Print) Linking ISSN: 08977194 NLM ISO Abbreviation: Growth Factors Subsets: MEDLINE

Publication: London : Informa Healthcare
Original Publication: Chur ; New York : Harwood Academic Publishers, 1988-

Gene Expression Regulation*; Inflammation/*metabolism ; Platelet-Derived Growth Factor/*metabolism ; Skin/*metabolism ; Spinal Cord Injuries/*complications ; Transforming Growth Factor beta1/*metabolism ; Wound Healing/*physiology; Animals ; Immunohistochemistry ; Inflammation/etiology ; Inflammation/genetics ; Leukocyte Count ; Male ; Platelet-Derived Growth Factor/genetics ; Rats ; Rats, Sprague-Dawley ; Skin/injuries ; Skin/pathology ; Transforming Growth Factor beta1/genetics ; Wounds and Injuries/pathology

At the cellular level, spinal cord injury (SCI) provokes an inflammatory response that generates substantial secondary damage within the cord, but also may contribute to its repair. The aim of this study was to investigate the effects of inflammatory response associated with SCI in cutaneous wound healing and on expression of transforming growth factor-beta1 (TGF-beta1) and platelet-derived growth factor (PDGF)-A at the wound site in rats. At the 14th day analysis, the mean TGF-beta1 score in trauma group (I) was significantly lower than that in control group (C) (2.60 +/- 0.90 vs. 3.64 +/- 0.37, respectively; p < 0.05). The mean score for PDGF-A expression in group I was similar to the corresponding value in group C (2.42 +/- 0.74 vs. 2.94 +/- 0.72, respectively). Compared to group C, group I had significantly lower mean scores for epidermal and dermal regeneration, but higher mean scores for granulation tissue thickness and similar scores for angiogenesis. The dermal layer contains diffuse deposition of collagen fibers that are not organised as in control rat skin, and intraepidermal and subepidermal vasocongestion is distinct. Based on the results on the parameters evaluated in the study, experimental SCI in rats results in delay in wound healing and low intensity of TGF-beta1 in the dorsal wound-tissue specimens.

0 (Platelet-Derived Growth Factor)
0 (Transforming Growth Factor beta1)
0 (platelet-derived growth factor A)

Date Created: 20080423 Date Completed: 20080807 Latest Revision: 20080422

20250114

10.1080/08977190802025339

18428026