Ozone–Oxygen Therapy to Prevent HPV-Related Cancers of the Lower Gynecological Tract in Infected Patients: The Rationale for Further Developments.

Simple Summary: The human papillomavirus (HPV) is the leading cause of infection-attributable cancers in women worldwide; among these, cervical cancer is the most common gynecological tumor and the second most frequent female-specific malignancy after breast cancer. Since virtually all carcinomas of the lower gynecological tract are due to high-risk HPV, new prevention strategies based on HPV eradication in infected patients are needed. Thanks to its well-known antiseptic properties, ozone–oxygen (O3-O2) therapy appears to be an interesting tool in order to achieve this goal by means of vaginal insufflation. Here, the rationale and guidelines for this prospective procedure are illustrated in detail. Background: O3-O2 therapy is an alternative medical treatment that introduces a mixture of O3-O2 into the body for therapeutic purposes. The objective of this study is to evaluate its margins of applicability in the eradication of HPV infection from the lower gynecological tract by means of vaginal insufflation. Methods: An in-depth review of the international literature on this topic is carried out; in addition, O3-O2 therapy is compared with other treatments currently available in terms of its advantages, disadvantages, and exploited technologies. Results: The possible benefits and limitations of O3-O2 vaginal insufflation are explained in detail; overall, it appears to be an interesting tool as part of complex management to prevent HPV-related cancers of the lower gynecological tract in infected patients. Conclusions: The rationale and guidelines of this innovative procedure have been successfully illustrated, providing the technical specifications for further developments. [ABSTRACT FROM AUTHOR]

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