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The effect of pinealectomy and leptin hormone on the proliferation and apoptosis activation in Syrian hamster testis in different photoperiods.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Gündüz B;Gündüz B; Karakaş A; Terzi H; Oner J; Serin E; Kükner A
  • المصدر:
    International journal of andrology [Int J Androl] 2009 Aug; Vol. 32 (4), pp. 343-52. Date of Electronic Publication: 2008 Jan 30.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Blackwell Country of Publication: England NLM ID: 8000141 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2605 (Electronic) Linking ISSN: 01056263 NLM ISO Abbreviation: Int J Androl Subsets: MEDLINE
    • بيانات النشر:
      Publication: : Oxford : Blackwell
      Original Publication: Copenhagen, Scriptor.
    • الموضوع:
      Apoptosis* ; Cell Proliferation* ; Photoperiod*; Leptin/*metabolism ; Pineal Gland/*surgery ; Seminiferous Tubules/*pathology ; Spermatogonia/*pathology; Animals ; Caspase 3/metabolism ; Cricetinae ; Injections, Intraperitoneal ; Leptin/administration & dosage ; Male ; Melatonin/metabolism ; Mesocricetus ; Pineal Gland/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Seminiferous Tubules/metabolism ; Spermatogonia/metabolism
    • نبذة مختصرة :
      The effects of pinealectomy and leptin hormone on proliferative and apoptotic processes in the epithelia of testicular seminiferous tubules of Syrian hamsters have been investigated. Proliferative and apoptotic processes were assessed semi-quantitatively by proliferating cell nuclear antigen (PCNA) and caspase-3 immune stainings. Animals used in the study were divided into four groups; control, pinealectomy (PinX), leptin-treated (10 microg/mL/day/kg body weight, intraperitoneally) and pinealectomy + leptin groups. Half of the hamsters in each group were exposed to short and the other half to long photoperiods for 8 weeks. In short photoperiod, PCNA activity especially in spermatogonia was significantly higher in the pinealectomy and leptin-treated groups compared with the control group. Histological score (HSCORE) value of PCNA in the PinX + leptin group was lower than those of PinX and leptin-treated groups. HSCORE value of caspase-3 in PinX and PinX + leptin groups was increased. In the long photoperiod, PCNA activation in the PinX group was significantly lower than the control group while the differences between the controls and other groups were not significant. The difference between the increases in caspase-3 activity in the PinX and control groups was significant. Thus, it was observed that photoperiods had no effect on the proliferation activity in the control groups. The inhibiting effect of short photoperiod on testis was not observed throughout 8 weeks. PinX eliminated the inhibiting effect of short photoperiod but did not alter the stimulating effect of long photoperiod. Leptin did not show any effect in long photoperiod but decreased proliferation by stimulating melatonin in short photoperiod.
    • الرقم المعرف:
      0 (Leptin)
      0 (Proliferating Cell Nuclear Antigen)
      EC 3.4.22.- (Caspase 3)
      JL5DK93RCL (Melatonin)
    • الموضوع:
      Date Created: 20080206 Date Completed: 20090924 Latest Revision: 20131121
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.1111/j.1365-2605.2008.00867.x
    • الرقم المعرف:
      18248398