نبذة مختصرة : Conventional nursing education, often based on functional models, suffers from inconsistencies in addressing pain management and patient risk. The increasing complexity of patient care necessitates a disciplined, repeatable training design. Simulation-based training (SBT) offers a safe, controlled environment to develop both technical and non-technical skills, bridging this gap. Advances in technology, from early models like Resusci Anne to high-fidelity surgical simulators, augmented reality (AR), virtual reality (VR), and standardized patients (SPs), have significantly expanded SBT's potential. Furthermore, the incorporation of biochemical simulations allows for a deeper understanding of underlying physiological processes and their impact on patient care. A thorough literature examination was performed utilizing databases including Google Scholar, Web of Science, and PubMed. Search terms included "simulation-based training," "clinical training," "clinical simulation," and "virtual simulation" to identify the research effectiveness of SBT in nursing. The review covers several variations of SBT, including dynamic fidelity simulation, VR/AR, SP, and hybrid simulations incorporating biochemical principles. The study showed convincing evidence of the effectiveness of SBT. High-fidelity simulators improve skills and retention, increase confidence, and reduce stress. VR/AR provides immersive experiences that are especially useful in surgical training. SPs improve communication and diagnosis. Integrated simulations combine different types of training that address both technical and non-technical skills. Debriefing sessions after simulations are important in terms of improving learning and performance. However, challenges remain, including large equipment and the need to continuously train teachers in simulation and presentation techniques. SBT, including its biochemical applications, is a highly effective tool for nursing education, improving clinical skills and patient safety. While financial and material constraints exist, particularly in low- and middle-income countries, technological advancements, such as AI customization and VR/AR application development, promise to broaden SBT's reach and impact. Future research should prioritize cost-effectiveness and global accessibility to ensure equitable access to high-quality simulation-based nursing education. [ABSTRACT FROM AUTHOR]
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