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Evaluation of Cystatin C as a biomarker of Severity of Coronary Artery Disease.

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  • معلومة اضافية
    • نبذة مختصرة :
      المقال يقيم إمكانيات السيستاتين C كعلامة حيوية لتقييم شدة مرض الشريان التاجي (CAD). أظهرت دراسة حالة-شاهد شملت 88 مشاركًا أن مستويات السيستاتين C في المصل كانت أعلى بشكل ملحوظ لدى مرضى CAD مقارنةً بالضوابط الصحية، مع وجود ارتباط إيجابي مع عوامل خطر القلب والأوعية الدموية المختلفة مثل كوليسترول LDL وسكر الدم الصائم. حددت الدراسة قيمة قطع للسيستاتين C أظهرت حساسية وخصوصية ملحوظتين لتشخيص CAD. بينما تشير النتائج إلى أن ارتفاع السيستاتين C قد يكون عامل خطر إضافي لمرض CAD، يبرز المقال عدم اليقين المستمر بشأن فعاليته كمؤشر حاسم لشدة CAD، مما يساهم في النقاش الأوسع حول فائدته السريرية في صحة القلب والأوعية الدموية. [Extracted from the article]
    • نبذة مختصرة :
      Background: Cystatin C has been associated with Coronary Artery Disease (CAD) even within normal ranges of Estimated glomerular filtration rate (eGFR) suggesting existence of GFR independent cystatin C mediated cardiovascular disease (CVD) risk. This study aimed to assess the relation between the biomarker and CV diseases. Methods: This is Case Control study which was conducted on 88 cases at departments of Medical Biochemistry and cardiac cath lab, Faculty of Medicine, Zagazig. Subjects enrolled in the study were divides into 2 groups: Group (I) included patients with CAD while Group (II) included healthy people with normal coronary artery. Every patient had a complete medical history taken, a routine clinical examination, laboratory testing, electrocardiography, coronary angiography and cystatin C assessment. Results: Compared to the control group, the cases group's serum cystatin C median levels increased in a statistically significant way. A statistically significant positive connection was seen between the Gensini score and the levels of TC, LDL, serum Cys-C and a positive significant correlation between serum Cys-C levels and both LDL and fasting blood glucose. ROC curve analysis was done during our study to show the values of cystatin C as a possible biomarker in CHD at (cut off =0.769), which had a sensitivity of 81.8% and a specificity of 69.1%, predictive values for positive (PVP) and negative (PVN) are 72%, 79%, and 75%, respectively, of accuracy. Conclusion: We concluded that high level of cystatin C is considered as an additional risk factor of coronary artery disease. [ABSTRACT FROM AUTHOR]
    • نبذة مختصرة :
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