Association of vitamin deficiency with the progression of anaemia.

المقال يركز على العلاقة بين نقص الفيتامينات وتطور فقر الدم، مسلطًا الضوء على الأدوار الحيوية للفيتامينات B-9 (حمض الفوليك) وB-12 (كوبالامين) في إنتاج كريات الدم الحمراء (RBC) وعملية تكوين الدم بشكل عام. يناقش كيف أن نقص كل من الفيتامينات القابلة للذوبان في الماء والفيتامينات القابلة للذوبان في الدهون يمكن أن يؤدي إلى أنواع مختلفة من فقر الدم من خلال تعطيل تخليق الحمض النووي، وإنتاج الهيموجلوبين، واستقلاب الحديد. تؤكد المراجعة أنه على الرغم من أن نقص الحديد يرتبط عادةً بفقر الدم، إلا أن نقص الفيتامينات يساهم أيضًا بشكل كبير في هذه الحالة. يُقترح إجراء مزيد من الأبحاث لاستكشاف التأثيرات الأوسع للفيتامينات الأخرى على فقر الدم وإنتاج كريات الدم الحمراء. [Extracted from the article]

Vitamins are micronutrients that play a vital role in the body's proper functioning and development. Furthermore, they are an essential requirement of the body for producing red blood cells (RBCs) and their growth. A particular quantity of micronutrients is mandatory for the regulation of body metabolism. Deficiency in vitamins leads to different types of anaemia in the body. Furthermore, deficiencies in both fat-soluble and water-soluble vitamins are linked to the destruction of RBCs. This review article was aimed at finding the correlation between the deficiency of vitamins and anaemia, with a major focus on the deficiency of vitamins B-9 and B-12 and their association with anaemia. In our deep observation of the literature, we found that the deficiency of vitamins causes iron malabsorption, haemoglobin (Hb) synthesis malfunctioning, impaired DNA synthesis, and a disturbed methylation cycle, while a disrupted erythropoiesis process and a reduction in the RBC's production leads to anaemia. Interference in vitamin B-9 and vitamin B-12-associated chemical reactions causes deficiency and results in diminished DNA synthesis. Malabsorption of vitamins B-9 and B-12 is a major concern for anaemia, but other water and fat-soluble vitamins disrupt iron metabolism and interrupt the erythropoiesis process, which ultimately causes anaemia. There should be a balanced number of vitamins in the diet; otherwise, this will inhibit the production of RBCs. As Vitamin B-9 and B-12 deficiencies have been associated with a reduction in DNA synthesis, further study is required to discover how additional fat-soluble and water-soluble vitamins affect DNA synthesis. [ABSTRACT FROM AUTHOR]

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