Mapping gut feelings and immune control.

REGULATORY T cells; KILLER cells; T helper cells; INTESTINAL barrier function; G proteins; THROMBIN receptors; TRYPTASE; HOMEOSTASIS

The article focuses on the discovery that dorsal root ganglion (DRG) sensory neurons play a crucial role in regulating regulatory T lymphocytes in the gut, highlighting the complexity of neuroimmune interactions. Topics include the gut's dual role in immune defense and tolerance, the use of comprehensive functional mapping to understand neuron-immune cell interactions, and the potential for new therapeutic approaches to chronic gastrointestinal diseases.