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Associations between 25 hydroxyvitamin D concentration and spontaneous abortion.
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- المؤلفون: Zhang, Hongping1 (AUTHOR); Ding, Xingru2 (AUTHOR); Hu, Xianqing1 (AUTHOR); Cai, Yi-Xin2 (AUTHOR); Chen, Haiying1 (AUTHOR); Sun, Congcong3 (AUTHOR); Chen, Jingjing1 (AUTHOR); Li, Xiaoqing3 (AUTHOR); Zheng, Zhenzhen1 (AUTHOR); Liao, Tingting1 (AUTHOR); Zhao, Na1 (AUTHOR); Zhong, Mingchen3 (AUTHOR); Fang, Rujing1 (AUTHOR); Huang, Xiu-Feng2 (AUTHOR) ; Zheng, Jianqiong1 (AUTHOR)
- المصدر:
BMC Public Health. 7/11/2024, Vol. 24 Issue 1, p1-8. 8p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Background: Spontaneous abortion is a common complication of pregnancy that can lead to adverse physical and psychological outcomes for women. Vitamin D is reported to be associated with reproductive functions, whereas its casual effects on abortion remains unclear. Materials and methods: In this study, a two-sample Mendelian randomization (MR) analysis was performed to systematically assess the causal relationships between serum 25 hydroxyvitamin D [25(OH)D] concentration and the risk of spontaneous abortion. GWAS summary data of 25(OH)D were used as exposure, and data of spontaneous abortion was considered as outcome. A retrospective study was additionally conducted to verify the MR results. Results: MR estimates showed that a higher 25(OH)D level was potentially associated with decreased risk of spontaneous abortion (IVW, OR = 0.98, 95%CI = 0.90–1.06; MR Egger, OR = 0.94, 95%CI = 0.84–1.05; Weighted median, OR = 0.93, 95%CI = 0.82–1.06; Weighted mode, OR = 0.93, 95%CI = 0.84–1.03), though the P-value was not statistically significant. The retrospective study also produced consistent result of Vitamin D's protective role to spontaneous abortion. The P-value was very close to statistical significance (P = 0.053). Conclusions: This study reports the potential protective role of serum 25(OH)D concentration to spontaneous abortion, suggesting that increased vitamin D levels may decrease the risk of abortion. Further larger prospective studies and/or even randomized controlled trials are needed to confirm causal relationship between vitamin D and abortion. [ABSTRACT FROM AUTHOR]
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