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Conditional survival and the prognostic value of serum carcinoembryonic antigen level in oldest old with colorectal cancer.
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- المؤلفون: He, Weijing1,2 (AUTHOR); Yang, Yufei1,2 (AUTHOR); Liu, Qi1,2 (AUTHOR); Luo, Dakui1,2 (AUTHOR); Li, Qingguo1,2 (AUTHOR); Li, Xinxiang1,2 (AUTHOR)
- المصدر:
BMC Gastroenterology. 7/10/2024, Vol. 24 Issue 1, p1-10. 10p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Background: To evaluate the clinical value of serum CEA levels and their implications on the diagnostic value of the conventional TNM staging system in the oldest-old patients with colorectal cancer (CRC). Methods: The recruited subjects were colorectal cancer patients aged 85 and older. The cutoff value for normal CEA level is 5 ng/mL. Patients with elevated CEA levels were categorized as stage C1, and those with normal CEA levels as stage C0. A number of Cox proportional hazard regression models were established to evaluate the prognosis of different prognostic factors with hazard ratios (HRs) and 95% confidence intervals (CIs). The Kaplan–Meier method was utilized to display the disparate prognostic impact of multiple clinicopathological factors with the log-rank test. Results: A total of 17,359 oldest-old patients diagnosed with CRC were recruited from the SEER database. The conditional survival of oldest-old patients with CRC was dismal with a 1-year conditional survival of only 11%, 18%, and 30% for patients surviving 1, 3, and 5 years, respectively. Patients with stage C1 exhibited a 48.5% increased risk of CRC-specific mortality compared with stage C0 (HR = 1.485, 95%CI = 1.393–1.583, using stage C0 patients as the reference, P < 0.001). All the stage C0 patients indicated lower HRs relative to the corresponding stage C1 patients. Conclusions: Dismal conditional survival of oldest-old patients with CRC should be given additional consideration. C stage influences the prognosis of oldest-old patients with CRC. [ABSTRACT FROM AUTHOR]
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