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TEŠKA FORMA DISTIROIDNE DERMOPATIJE KOD PACIJENTA SA HIPERTIREOZOM.
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- المؤلفون: Đurković, Ivana1; Stojković, Mirjana1,2; Marković, Bojan1; Klet, Sanja1; Janić, Tamara1; Babić, Jovana1; Beleslin, Biljana Nedeljković1,2; Cirić, Jasmina1,2; Žarković, Miloš1,2
- المصدر:
Medical Gazette / Medicinski Glasnik. jun2024, Vol. 29 Issue 93, p20-31. 12p.
- معلومة اضافية
- Alternate Title:
SEVERE FORM OF THYROID DERMOPATHY IN PATIENT WITH HYPERTHYROIDISM.
- نبذة مختصرة :
Graves’ disease is an autoimmune disorder in which TSH receptor antibodies play the main pathogenic role. Besides the usual clinical presentation as hyperthyroidism, extrathyroidal manifestations can develop. Thyroid dermopathy is one of them and it is present in about 0.5-4.3% of cases, mostly in patients with thyroid orbitopathy as main extrathyroidal manifestation. Dermopathy can manifest in different forms: non-pitting edema, plaques, nodules and elephantiasis. We are reporting a case of a patient with thyrotoxicosis caused by Graves’ disease with ocular extrathyroidal manifestation and dermopathy in elephantiasis form, confirmed by punch biopsy. Corticosteroid therapy significantly improved ocular manifestations, as well as skin lesions. Elephantiasis represents the most severe form of this disease and can be resistant to any treatment thus why it is a major therapeutic challenge. [ABSTRACT FROM AUTHOR]
- نبذة مختصرة :
Grejvsova bolest (GB) je autoimunski poremećaj u čijoj su osnovi patogenetskog mehanizma TSH receptorska antitela. Osim uobičajene kliničke slike hipertireoze, mogu biti prisutne i ekstratiroidne manifestacije. Distirodina dermopatija je jedna od njih i javlja se kod oko 0.5-4.3% slučajeva, uglavnom kod pacijenata sa već prisutnom distiroidnom orbitopatijom kao najčešćom ekstratiroidnom manifestacijom. Javlja se u različitim formama netestastih edema, plakova, čvorova i retko u obliku elefantijaza. Prikazali smo pacijenta sa tireotoksikozom na terenu GB kod kog je bila prisutna okularna ekstratiroidna manifestacija, kao i distiroidna dermopatija u obliku elefantijaze, koja je dokazana punch biopsijom. Na primenu kortikosteroidne terapije kod pacijenta je došlo do značajnog poboljšanja nalaza na očima, kao i poboljšanja dermopatije. Elefantijaza predstavlja najtežu formu ovog oboljenja i može biti rezistentna na bilo koji vid lečenja zbog čega predstavlja veliki terapijski izazov. [ABSTRACT FROM AUTHOR]
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