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Pharmacokinetics and pharmacodynamics of intravenously and subcutaneously administered pantoprazole in sheep (Ovis aries).
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- المؤلفون: Smith, Joe S.1,2 (AUTHOR) ; Bennett, Kailee1 (AUTHOR); Flynn, Ryan1 (AUTHOR); Gebert, Jesse3 (AUTHOR); Mulon, Pierre-Yves1 (AUTHOR); Garcia, Jessica D.1 (AUTHOR); Harvill, Lainey4 (AUTHOR); Escher, Olivia1 (AUTHOR); Ebner, Lisa Sams3 (AUTHOR); Bergman, Joan4 (AUTHOR); Cox, Sherry4 (AUTHOR)
- المصدر:
PLoS ONE. 6/12/2024, Vol. 19 Issue 6, p1-13. 13p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Abomasal ulcers are recognized in sheep of all ages, but research regarding therapeutic interventions is limited. Proton Pump Inhibitors (PPIs) such as pantoprazole, are clinically used with a paucity of evidence regarding efficacy in mature sheep. Intravenous and subcutaneously administered pantoprazole dosed at 1.0 mg/kg in adult sheep will increase the pH of abomasal fluid compared to pre-administration baseline. The objectives were to assess the effect of pantoprazole, after single and multiple administration, on abomasal fluid pH in adult sheep. A third objective was to describe the pharmacokinetic parameters of IV and SC pantoprazole. Four clinically healthy adult Southdown ewes previously fitted with a gastrostomy tube in the abomasum were utilized in this randomized, 2-way cross-over trial. Ewes received pantoprazole (1.0 mg/kg) as a single and 3-dose regimen (every 24 hours). After a 10 day washout period the reverse treatment was applied. Blood for analysis of pantoprazole concentration was collected intermittently for 24 hours, and abomasal fluid pH was measured at intervals for a 96-hour period. The pH of the abomasal fluid was higher in pantoprazole treatments for up to 24 hours after dosing. Following intravenous administration of pantoprazole to study ewes, elimination half-life, volume of distribution, and clearance of pantoprazole was estimated as 3.29 hours, 0.35 L/kg, and 65.26 mL/hr/kg respectively. After subcutaneous dosing, maximum concentration, time to maximum concentration, half-life of elimination, and volume of distribution, were estimated as 2604 ng/mL, 0.55 hours, 2.48 hours, and 0.37 L/kg. Additionally, the bioavailability was estimated as 83.33%. Pantoprazole administered IV or SC may be useful for treatment or prevention of abomasal ulcers in adult sheep. [ABSTRACT FROM AUTHOR]
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