White matter abnormalities in drug-naïve patients with obsessive-compulsive disorder: a diffusion tensor study before and after citalopram treatment.

Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 0370364 Publication Model: Print Cited Medium: Print ISSN: 0001-690X (Print) Linking ISSN: 0001690X NLM ISO Abbreviation: Acta Psychiatr Scand Subsets: MEDLINE

Publication: Malden, MA : Wiley-Blackwell
Original Publication: Copenhagen : Munksgaard International Publishers

Diffusion Magnetic Resonance Imaging* ; Image Processing, Computer-Assisted* ; Magnetic Resonance Imaging*; Antidepressive Agents, Second-Generation/*therapeutic use ; Brain/*drug effects ; Citalopram/*therapeutic use ; Nerve Fibers, Myelinated/*drug effects ; Obsessive-Compulsive Disorder/*drug therapy; Adult ; Anisotropy ; Antidepressive Agents, Second-Generation/adverse effects ; Caudate Nucleus/drug effects ; Caudate Nucleus/pathology ; Cerebral Cortex/drug effects ; Cerebral Cortex/pathology ; Citalopram/adverse effects ; Corpus Callosum/drug effects ; Corpus Callosum/pathology ; Dominance, Cerebral/physiology ; Female ; Fourier Analysis ; Humans ; Internal Capsule/drug effects ; Internal Capsule/pathology ; Male ; Nerve Fibers, Myelinated/pathology ; Obsessive-Compulsive Disorder/diagnosis ; Thalamus/drug effects ; Thalamus/pathology

Objective: The aim was to investigate the white matter abnormalities of drug-naïve patients with obsessive-compulsive disorder (OCD) using diffusion tensor-imaging and the white matter changes in the patients after pharmacotherapy.
Method: Thirteen drug-naïve OCD patients and 13 age- and sex-matched healthy comparison subjects were examined using diffusion tensor-imaging and structural magnetic resonance imaging. Measurements were made in OCD patients before and after 12 weeks of citalopram treatment.
Results: Compared with controls, the drug-naïve OCD patients showed significant increases in fractional anisotropy (FA) in the corpus callosum, the internal capsule and white matter in the area superolateral to the right caudate. The increases in FA were mostly no longer observed in patients after 12 weeks of treatment compared with controls.
Conclusion: Our findings suggest that white matter alterations are associated with the pathophysiology of OCD, and the abnormalities may be partly reversible with pharmacotherapy.

0 (Antidepressive Agents, Second-Generation)
0DHU5B8D6V (Citalopram)

Date Created: 20070728 Date Completed: 20071018 Latest Revision: 20220318

20221213

10.1111/j.1600-0447.2007.01046.x

17655563