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Neural and Onconeural Autoantibodies and Blood–Brain Barrier Disruption Markers in Patients Undergoing Radiotherapy for High-Grade Primary Brain Tumour.
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- المؤلفون: Hojan, Katarzyna1,2 (AUTHOR) ; Adamska, Krystyna3,4 (AUTHOR) ; Lewandowska, Agnieszka3 (AUTHOR) ; Procyk, Danuta5 (AUTHOR) ; Leporowska, Ewa5 (AUTHOR) ; Osztynowicz, Krystyna6 (AUTHOR) ; Michalak, Slawomir6,7 (AUTHOR)
- المصدر:
Diagnostics (2075-4418). Feb2024, Vol. 14 Issue 3, p307. 12p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Radiotherapy (RT) plays a key role in brain tumours but can negatively impact functional outcomes and quality of life. The aim of this study was to analyse anti-neural and onconeural autoantibodies and markers of blood–brain barrier (BBB) disruption in patients with primary brain cancer undergoing RT. Materials and methods. A prospective study was conducted on 45 patients with a brain tumour scheduled for intensity-modulated radiotherapy. Assessments were performed at baseline, post-RT, and at three months. We measured serum levels of BBB disruption biomarkers and anti-neural, onconeural, and organ-specific antibodies. Results. Antibodies against nucleosome antigens and neuronal surface antigens were detected in 85% and 3% of cases, respectively; anti-neural and onconeural antibodies were observed in 47% and 5.8%. In 44% patients, ≥2 antibody types were detected. No significant changes in BBB biomarkers were observed. Conclusion. The findings of this study show that a humoral immune response is common in patients undergoing RT for brain cancer. This response appears to be non-organ specific but rather directed against nucleosome antigens, but onconeural antibodies were uncommon, suggesting a low risk of a neurological paraneoplastic syndrome. Our data suggested that radiotherapy may not affect BBB integrity, but larger studies are needed to better characterise the pathophysiological effects of RT. [ABSTRACT FROM AUTHOR]
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