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HIF-1alpha expression regulates the bactericidal capacity of phagocytes.
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- المؤلفون: Peyssonnaux, Carole1; Datta, Vivekanand2; Cramer, Thorsten1; Doedens, Andrew1; Theodorakis, Emmanuel A.3; Gallo, Richard L.2,4; Hurtado-Ziola, Nancy4; Nizet, Victor2; Johnson, Randall S.1
- المصدر:
Journal of Clinical Investigation. Jul2005, Vol. 115 Issue 7, p1806-1815. 10p. 1 Diagram, 7 Graphs.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Hypoxia is a characteristic feature of the tissue microenvironment during bacterial infection. Here we report on our use of conditional gene targeting to examine the contribution of hypoxia-inducible factor 1, alpha subunit (HIF-1alpha) to myeloid cell innate immune function. HIF-1alpha was induced by bacterial infection, even under normoxia, and regulated the production of key immune effector molecules, including granule proteases, antimicrobial peptides, nitric oxide, and TNF-alpha. Mice lacking HIF-1alpha in their myeloid cell lineage showed decreased bactericidal activity and failed to restrict systemic spread of infection from an initial tissue focus. Conversely, activation of the HIF-1alpha pathway through deletion of von Hippel-Lindau tumor-suppressor protein or pharmacologic inducers supported myeloid cell production of defense factors and improved bactericidal capacity. HIF-1alpha control of myeloid cell activity in infected tissues could represent a novel therapeutic target for enhancing host defense. [ABSTRACT FROM AUTHOR]
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